Quantitative and Probabilistic Modeling in Pathway Logic

A. Abate and Y. Bai and N. Sznajder and C. Talcott and A. Tiwari

Presented at BIBE 2007, Boston, Oct 14-17, 2007.


This paper presents a study of possible extensions of Pathway Logic to represent and reason about semiquantitative and probabilistic aspects of biological processes. The underlying theme is the annotation of reaction rules with affinity information that can be used in different simulation strategies. Several such strategies were implemented, and experiments carried out to test feasibility, and to compare results of different approaches. Dimerization in the ErbB signalling network, important in cancer biology, was used as a test case.

Research supported in part by the National Science Foundation under grants IIS-0513857 and ITR-CCR-0326540 and by the Public Health Service grant GM068146-03 from the National Institute of General Medical Sciences.

pdf. All IEEE 7th BIBE papers are now on-line digital at IEEE Xplore Please visit IEEE Xplore website directly or search or browse for Bioinformatics and Bioengineering, 2007. BIBE 2007 Proceedings of the 7th IEEE International Conference on or search by date by clicking on Date: Oct 14-17, 2007


Slides of the presentation at BIBE'07 may be put up here later ...

BibTeX Entry

        AUTHOR = {A. Abate and Y. Bai and N. Sznajder and C. Talcott and A. Tiwari},
        TITLE = {Quantitative and Probabilistic Modeling in Pathway Logic},
        BOOKTITLE = {Proc. 7th {IEEE} Intl. Conf. on BioInformatics and BioEngineering, BIBE07},
        PAGES = {922-929},
        MONTH = {Oct},
        YEAR = {2007},
        ADDRESS = {Boston, MA},

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