Simulation ID Objective Contraints Evaluator Comment Solution: imports Solution: exports c m r p l n s b Transport Carbohydrate and energy metabolism sugarburn-to-ATP ATP(c) -Glucose(s) -Pi(c) -ADP(c) +CO2(c) -O2(s) =H2O(s) Glucose(s) test that external glucose can completely be oxidized to CO2 while exclusively rephosphorylating ADP to ATP 0.193548 O2(s) 1 ADP(c) 1 Pi(c) 0.0322581 Glucose(s) 1.19354838709677 H2O(s) 0.99999999999997 ATP(c) 0.193548387096774 CO2(c) 12 11 - - - - - - 14 sugarburn-to-NADH NADH(c) -Glucose(s) -NAD+(c) +CO2(c) -O2(s) =H2O(s) Glucose(s) test that external glucose can completely be oxidized to CO2 while exclusively reducing NAD+ to NADH 0.486146 H2O(s) 1 NAD+(c) 0.0138539 O2(s) 0.0856423 Glucose(s) 0.99999999999997 NADH(c) 0.513853904282116 CO2(c) 26 8 - - - - - - 16 sugarburn-to-NAPDH NADPH(c) -Glucose(s) -NADP+(c) +CO2(c) -O2(s) =H2O(s) Glucose(s) test that external glucose can completely be oxidized to CO2 while exclusively reducing NADP+ to NADPH 0.485714 H2O(s) 1 NADP+(c) 0.0142857 O2(s) 0.0857143 Glucose(s) 0.99999999999997 NADPH(c) 0.514285714285714 CO2(c) 25 8 - - - - - - 16 oxidative phosphorylation ATP(c) -NADH(c) -ADP(c) -O2(c) +H2O(c) -Pi(c) +NAD+(c) NADH(c) test the exidative phosphorylation, conversion of cytosolic NADH/NAD gradient into cytosolic ADP rephosphorylation to ATP 0.666667 NADH(c) 0.333333 O2(c) 1 ADP(c) 1 Pi(c) 1.66666666666667 H2O(c) 0.99999999999997 ATP(c) 0.666666666666666 NAD+(c) 1 - - - - - - - 8 oxidative decarboxylation NADH(m) -Pyruvate(m) -NAD+(m) +CO2(m) +Acetyl-CoA(m) -CoA(m) Pyruvate(m) test that NADH/NAD potential can be build up by converting mitochondrial pyruvate to CO2 while acetylating CoA 1 NAD+(m) 1 CoA(m) 1 Pyruvate(m) 0.99999999999997 NADH(m) 1 CO2(m) 1 Acetyl-CoA(m) - 1 - - - - - - - Krebs cycle NADH NADH(m) -Pyruvate(m) +ATP(m) -ADP(m) -Pi(m) -NAD+(m) +CO2(s) -O2(s) Pyruvate(m) 1 NAD+(m) 0.125 O2(s) 0.5 ADP(m) 0.5 Pi(m) 0.25 Pyruvate(m) 0.5 ATP(m) 0.99999999999997 NADH(m) 0.75 CO2(s) - 15 - - - - - - 7 ATP-for-free ATP(m) -ADP(m) -Pi(m) =H2O(s) exclude(s) exclude that mitochondrial ADP can be rephosphyrylated without any other exchange of substrates - - - - - - - - - Proton-for-free H+(PG)(c) -H+(PG)(m) exclude(s) exclude that the mitochondrial/cytosolic proton gradient can be build up without any other exchange of substrates - - - - - - - - - NADH-for-free NADH(m) -NAD+(m) exclude(s) exclude that mitochondrial NAD+ can be reduced to NADH without any other exchange of substrates - - - - - - - - - NADPH-for-free NADPH(c) -NADP+(c) =CO2(s) =O2(s) exclude(s) exclude that mitochondrial NADP+ can be reduced to NADPH without any other exchange of substrates - - - - - - - - - ATP-from-NADH ATP(c) -ADP(c) -Pi(c) +NAD+(m) -NADH(m) =H2O(s) -O2(s) NADH(m) test that NADH/NAD+ potential can be transformed to ATP/ADP potential 0.4 NADH(m) 0.2 O2(s) 1 ADP(c) 1 Pi(c) 1.4 H2O(s) 0.99999999999997 ATP(c) 0.4 NAD+(m) - - - - - - - - 10 NADH-from-ATP NADH(m) -ATP(c) +ADP(c) +Pi(c) +NAD+(m) =H2O(s) -O2(s) exclude(s) test that ATP/ADP potential can be transformed to NADH/NAD+ potential - - - - - - - - - Glucose-for-free Glucose(s) -CO2(s) -ATP(c) +ADP(c) +Pi(c) +O2(s) exclude(s) exclude that glucose can be produced from CO2 and ATP/ADP gradient while possibly wasting O2 - - - - - - - - - Ubiquinol-to-proton H+(PG)(c) -H+(PG)(m) +Ubiquinone(m) -Ubiquinol(m) =H2O(m) -O2(m) Ubiquinol(m) test that mitochondrial Ubiquinol/Ubiquinone gradient without any exchange of substrates 0.0833333 O2(m) 1 H+(PG)(m) 0.166667 Ubiquinol(m) 0.166666666666667 H2O(m) 0.99999999999997 H+(PG)(c) 0.166666666666667 Ubiquinone(m) - - - - - - - - 2 Ubiquinol-to-ATP ATP(c) -ADP(c) -Pi(c) +Ubiquinone(m) -Ubiquinol(m) =H2O(m) -O2(m) Ubiquinol(m) test that mitochondrial ATP/ADP potential without any exchange of substrates 0.333333 O2(m) 1 ADP(c) 1 Pi(c) 0.666667 Ubiquinol(m) 1.66666666666667 H2O(m) 0.99999999999997 ATP(c) 0.666666666666667 Ubiquinone(m) - - - - - - - - 5 Methylgroup 5-Methyl-THF(c) -THF(c) MES 5-Methyl-THF(c) test that the methyl group on THF can be regenerated from the minimal exchange set 1.5 H2O(s) 2.5 O2(s) 1 Histidine(s) 1 Folate(s) 3.5 CO2(s) 1.5 Urea(s) 0.99999999999997 5-Methyl-THF(c) 30 14 - - - - - - 25 Formylgroup 10-Formyl-THF(c) -THF(c) MES 10-Formyl-THF(c) test that the methyl group on THF can be regenerated from the minimal exchange set 0.5 H2O(s) 3.5 O2(s) 1 Histidine(s) 1 Folate(s) 3.5 CO2(s) 1.5 Urea(s) 0.99999999999997 10-Formyl-THF(c) 30 13 - - - - - - 25 Thioredoxin_oxidation Oxidized_thioredoxin(c) MES -Thioredoxin(c) Oxidized_thioredoxin(c) test that cytosolic thioredoxin can be oxidized using the minimal exchange set 0.5 O2(s) 1 Thioredoxin(c) 1 H2O(s) 0.99999999999997 Oxidized_thioredoxin(c) 12 - - - - - - - 10 Thioredoxin_reduction Thioredoxin(c) MES -Oxidized_thioredoxin(c) Thioredoxin(c) test that cytosolic thioredoxin can be reduced using the minimal exchange set 0.485714 H2O(s) 0.0142857 O2(s) 0.0857143 Glucose(s) 1 Oxidized_thioredoxin(c) 0.514285714285714 CO2(s) 0.99999999999997 Thioredoxin(c) 25 9 - - - - - - 16 ATP-energy ATP-energy(c) MES ATP-energy(c) test that the ATP energy pseudo metabolite can be produced in the cytosol from the minimal exchange set 0.21327 O2(s) 0.00947867 Palmitolate(s) 0.14218009478673 H2O(s) 0.151658767772512 CO2(s) 0.99999999999997 ATP-energy(c) 8 39 - - - - - - 15 NADH-redox-potential NADH-redox-potential(c) MES NADH-redox-potential(c) test that the pseudo metabolite NADH-redox-potential can be produced in the cytosol from the minimal exchange set 0.486146 H2O(s) 0.0138539 O2(s) 0.0856423 Glucose(s) 0.513853904282116 CO2(s) 0.99999999999997 NADH-redox-potential(c) 27 8 - - - - - - 17 NADPH-redox-potential NADPH-redox-potential(c) MES NADPH-redox-potential(c) test that the pseudo metabolite NADPH-redox-potential can be produced in the cytosol from the minimal exchange set 0.485714 H2O(s) 0.0142857 O2(s) 0.0857143 Glucose(s) 0.514285714285714 CO2(s) 0.99999999999997 NADPH-redox-potential(c) 25 9 - - - - - - 17 activated-sulphur activated-sulphur(c) MES activated-sulphur(c) test that the pseudo metabolite activated-sulphur can be produced in the cytosol from the minimal exchange set 0.63981 O2(s) 1 Sulfate(s) 0.028436 Palmitolate(s) 1.42654028436019 H2O(s) 0.454976303317535 CO2(s) 0.99999999999997 activated-sulphur(c) 11 39 - - - - - - 19 Proton-gradient(m) -1 Proton-gradient(m) MES Proton-gradient(m) test that the pseudo metabolite Proton-gradient can be wasted (this is equivalent to build up the normal cyto/mito proton gradient) from the minimal exchange set 0.0556931 O2(s) 0.00247525 Palmitolate(s) 1 Proton-gradient(m) 0.0371287128712871 H2O(s) 0.0396039603960396 CO2(s) 7 43 - - - - - - 15 Proton-gradient(c) Proton-gradient(c) MES Proton-gradient(c) test that the pseudo metabolite Proton-gradient in cytosol (this is equivalent to build up the proton gradient on the outer membrane for transport processes) can be produced from the minimal exchange set 0.99999999999997 Proton-gradient(c) - - - - - - - - 3 Activated_methyl_group(c) Activated_methyl_group(c) MES Activated_methyl_group(c) test that the pseudo metabolite Activated_methyl_group can be produced in the cytosol from the minimal exchange set 3.5 O2(s) 1 Histidine(s) 0.500000000000021 H2O(s) 3.49999999999999 CO2(s) 1.5 Urea(s) 0.99999999999997 Activated_methyl_group(c) 34 12 - - - - - - 24 palmitateburn-to-ATP ATP(c) -Palmitate(s) -Pi(c) -ADP(c) +CO2(c) -O2(s) =H2O(c) Palmitate(s) test that external palmitate can completely be oxidized to CO2 while exclusively rephosphorylating ADP to ATP 0.221154 O2(s) 1 ADP(c) 1 Pi(c) 0.00961538 Palmitate(s) 1.15384615384615 H2O(c) 0.99999999999997 ATP(c) 0.153846153846154 CO2(c) 4 39 - - - - - - 12 Glycogen-storage Glycogenin-G4G7(c) -Glycogenin(c) -Glucose(s) -O2(s) +CO2(s) =H2O(s) Glycogenin-G4G7(c) test the storage of glucose in a glycogen component 4.25806 O2(s) 11.7097 Glucose(s) 1 Glycogenin(c) 15.258064516129 H2O(s) 4.25806451612903 CO2(s) 0.99999999999997 Glycogenin-G4G7(c) 18 11 - - - - - - 16 Glycogen-glucose-release Glucose(s) -Glycogenin-G4G7(c) +Glycogenin(c) -Glucose(s) -O2(s) +CO2(s) =H2O(s) Glucose(s) test the release of glucose from a glycogen component 1 H2O(s) 0.0909091 Glycogenin-G4G7(c) 0.99999999999997 Glucose(s) 0.0909090909090909 Glycogenin(c) 5 - 1 - - - - - 5 CO2_export CO2(s) -CO2(c) -Glucose(s) -O2(s) =H2O(s) CO2(s) tests that carbon dioxide can be excreted 1 CO2(c) 0.99999999999997 CO2(s) - - - - - - - - 1 Na+_exportgradient Na+(c) -Na+(s) -Glucose(s) -O2(s) +CO2(s) +H2O(s) Na+(c) tests that natrium can be pumped into the cell 1 Na+(s) 0.99999999999997 Na+(c) - - - - - - - - 2 Na+_importgradient Na+(s) -Na+(c) -Glucose(s) -O2(s) +CO2(s) +H2O(s) Na+(c) tests that natrium can be pumped into the cell 0.193548 O2(s) 0.0322581 Glucose(s) 1 Na+(c) 0.193548387096774 H2O(s) 0.193548387096774 CO2(s) 0.99999999999997 Na+(s) 12 11 - - - - - - 18 Metabolism of purins and pyrimidines ATP(s) ATP(s) MES ATP(s) test that ATP can be produced and excreted into the blood from the minimal exchange set 5.5 O2(s) 3 Pi(s) 2 NH3(s) 1.33333 Glucose(s) 1 Histidine(s) 12 H2O(s) 0.99999999999997 ATP(s) 4 CO2(s) 54 12 - - - - - - 31 CTP(c) CTP(c) MES CTP(c) test that cytosolic CTP can be produced from the minimal exchange set 2.74419 O2(s) 3 Pi(s) 1.54651 NH3(s) 0.908915 Glucose(s) 0.302326 Histidine(s) 0.546512 Valine(s) 8.63953488372093 H2O(s) 1 CO2(s) 0.99999999999997 CTP(c) 38 18 - - - - - - 32 GDP(c) GDP(c) MES GDP(c) test that cytosolic GTP can be produced from the minimal exchange set 6 O2(s) 2 Pi(s) 2 NH3(s) 1.33333 Glucose(s) 1 Histidine(s) 11 H2O(s) 4 CO2(s) 0.99999999999997 GDP(c) 54 11 - - - - - - 30 UTP(c) UTP(c) MES UTP(c) test that cytosolic UTP can be produced from the minimal exchange set 2.51163 O2(s) 3 Pi(s) 0.406977 NH3(s) 0.932171 Glucose(s) 0.395349 Histidine(s) 0.406977 Valine(s) 7.22093023255814 H2O(s) 1 CO2(s) 0.99999999999997 UTP(c) 36 19 - - - - - - 31 dATP(c) dATP(c) MES dATP(c) test that cytosolic dATP can be produced from the minimal exchange set 5 O2(s) 3 Pi(s) 2 NH3(s) 1.33333 Glucose(s) 1 Histidine(s) 12 H2O(s) 3.99999999999999 CO2(s) 0.99999999999997 dATP(c) 55 13 - - - - - - 30 dCTP(c) dCTP(c) MES dCTP(c) test that cytosolic dCTP can be produced from the minimal exchange set 2.63035 O2(s) 3 Pi(s) 0.837224 Glucose(s) 0.953307 Histidine(s) 0.140078 Valine(s) 6.58365758754864 H2O(s) 2.44357976653697 CO2(s) 0.99999999999997 dCTP(c) 36 22 - - - - - - 28 dGTP(c) dGTP(c) MES dGTP(c) test that cytosolic dGTP can be produced from the minimal exchange set 5.5 O2(s) 3 Pi(s) 2 NH3(s) 1.33333 Glucose(s) 1 Histidine(s) 12 H2O(s) 4 CO2(s) 0.99999999999997 dGTP(c) 55 12 - - - - - - 31 dTTP(c) dTTP(c) MES dTTP(c) test that cytosolic dTTP can be produced from the minimal exchange set 2.98843 O2(s) 3 Pi(s) 1.13721 Glucose(s) 1 Histidine(s) 0.029563 Palmitolate(s) 6.76670951156813 H2O(s) 2.79627249357327 CO2(s) 0.5 Urea(s) 0.99999999999997 dTTP(c) 58 46 - - - - - - 30 UDP-glucuronate(c) UDP-glucuronate(c) MES UDP-glucuronate(c) test that cytosolic UDP-glucuronate can be produced from the minimal exchange set 2.81915 O2(s) 2 Pi(s) 0.0212766 NH3(s) 2.00355 Glucose(s) 0.659574 Histidine(s) 7.02127659574468 H2O(s) 0.978723404255319 CO2(s) 0.99999999999997 UDP-glucuronate(c) 41 10 - - - - - - 31 UDP-galactose(c) UDP-galactose(c) MES UDP-galactose(c) test that cytosolic UDP-galactose can be produced from the minimal exchange set (galactose can not be produced in liver!) 2.51163 O2(s) 2 Pi(s) 0.406977 NH3(s) 1.93217 Glucose(s) 0.395349 Histidine(s) 0.406977 Valine(s) 7.22093023255814 H2O(s) 1 CO2(s) 0.99999999999997 UDP-galactose(c) 38 19 - - - - - - 32 UDP-glucose(c) UDP-glucose(c) MES UDP-glucose(c) test that cytosolic UDP-glucose can be produced from the minimal exchange set 2.51163 O2(s) 2 Pi(s) 0.406977 NH3(s) 1.93217 Glucose(s) 0.395349 Histidine(s) 0.406977 Valine(s) 7.22093023255814 H2O(s) 1 CO2(s) 0.99999999999997 UDP-glucose(c) 37 19 - - - - - - 32 GDP-L-fucose(c) GDP-L-fucose(c) MES GDP-L-fucose(c) test that cytosolic GDP-L-fucose can be produced from the minimal exchange set 5.5 O2(s) 2 Pi(s) 2 NH3(s) 2.33333 Glucose(s) 1 Histidine(s) 12 H2O(s) 4 CO2(s) 0.99999999999997 GDP-L-fucose(c) 60 12 - - - - - - 29 GDP-mannose(c) GDP-mannose(c) MES GDP-mannose(c) test that cytosolic GDP-mannose can be produced from the minimal exchange set 6 O2(s) 2 Pi(s) 2 NH3(s) 2.33333 Glucose(s) 1 Histidine(s) 12 H2O(s) 4 CO2(s) 0.99999999999997 GDP-mannose(c) 57 11 - - - - - - 31 UDP-xylose(c) UDP-xylose(c) MES UDP-xylose(c) test that cytosolic UDP-xylose can be produced from the minimal exchange set 2.81915 O2(s) 2 Pi(s) 0.0212766 NH3(s) 2.00355 Glucose(s) 0.659574 Histidine(s) 7.02127659574468 H2O(s) 1.97872340425532 CO2(s) 0.99999999999997 UDP-xylose(c) 41 10 1 - - - - - 34 ADP(c) ADP(c) MES ADP(c) test that cytosolic ADP can be produced from the minimal exchange set 5.5 O2(s) 2 Pi(s) 2 NH3(s) 1.33333 Glucose(s) 1 Histidine(s) 11 H2O(s) 0.99999999999997 ADP(c) 4 CO2(s) 53 12 - - - - - - 31 AMP(c) AMP(c) MES AMP(c) test that cytosolic AMP can be produced from the minimal exchange set 5.5 O2(s) 1 Pi(s) 2 NH3(s) 1.33333 Glucose(s) 1 Histidine(s) 9.99999999999998 H2O(s) 3.99999999999999 CO2(s) 0.99999999999997 AMP(c) 54 10 - - - - - - 30 IMP(c) IMP(c) MES IMP(c) test that cytosolic IMP can be produced from the minimal exchange set 5.5 O2(s) 1 Pi(s) 1 NH3(s) 1.33333 Glucose(s) 1 Histidine(s) 8.99999999999997 H2O(s) 3.99999999999999 CO2(s) 0.99999999999997 IMP(c) 55 10 - - - - - - 29 Xanthosine-5P(c) Xanthosine-5P(c) MES Xanthosine-5P(c) test that cytosolic Xanthosine-5P can be produced from the minimal exchange set 6 O2(s) 1 Pi(s) 1 NH3(s) 1.33333 Glucose(s) 1 Histidine(s) 9 H2O(s) 4 CO2(s) 0.99999999999997 Xanthosine-5P(c) 57 9 - - - - - - 29 GMP(c) GMP(c) MES GMP(c) test that cytosolic GMP can be produced from the minimal exchange set 6 O2(s) 1 Pi(s) 2 NH3(s) 1.33333 Glucose(s) 1 Histidine(s) 10 H2O(s) 4.00000000000001 CO2(s) 0.99999999999997 GMP(c) 54 11 - - - - - - 29 GTP(c) GTP(c) MES GTP(c) test that cytosolic GTP can be produced from the minimal exchange set 6 O2(s) 3 Pi(s) 2 NH3(s) 1.33333 Glucose(s) 1 Histidine(s) 12 H2O(s) 3.99999999999999 CO2(s) 0.99999999999997 GTP(c) 54 11 - - - - - - 31 Uracil(c) Uracil(c) MES Uracil(c) test that cytosolic Uracil can be produced from the minimal exchange set 1.16667 O2(s) 1 NH3(s) 0.333333 Glucose(s) 0.333333 Histidine(s) 3 H2O(s) 0.99999999999997 Uracil(c) 36 9 - - - - - - 23 Uridine(c) Uridine(c) MES Uridine(c) test that cytosolic Uridine can be produced from the minimal exchange set 1.24286 O2(s) 0.885714 NH3(s) 1.14762 Glucose(s) 0.371429 Histidine(s) 3.88571428571429 H2O(s) 0.114285714285715 CO2(s) 0.99999999999997 Uridine(c) 39 10 - - - - - - 23 UMP(c) UMP(c) MES UMP(c) test that cytosolic UMP can be produced from the minimal exchange set 1.64894 O2(s) 1 Pi(s) 0.276596 NH3(s) 1.0461 Glucose(s) 0.574468 Histidine(s) 4.27659574468085 H2O(s) 0.72340425531915 CO2(s) 0.99999999999997 UMP(c) 37 10 - - - - - - 30 UDP(c) UDP(c) MES UDP(c) test that cytosolic UDP can be produced from the minimal exchange set 2.04651 O2(s) 2 Pi(s) 0.127907 NH3(s) 0.978682 Glucose(s) 0.581395 Histidine(s) 0.127907 Valine(s) 5.38372093023256 H2O(s) 1 CO2(s) 0.99999999999997 UDP(c) 35 19 - - - - - - 31 Cytidine(c) Cytidine(c) MES Cytidine(c) test that cytosolic Cytidine can be produced from the minimal exchange set 1.47143 O2(s) 1.54286 NH3(s) 1.09048 Glucose(s) 0.485714 Histidine(s) 4.54285714285714 H2O(s) 0.457142857142858 CO2(s) 0.99999999999997 Cytidine(c) 46 9 - - - - - - 24 CMP(c) CMP(c) MES CMP(c) test that cytosolic CMP can be produced from the minimal exchange set 1.81915 O2(s) 1 Pi(s) 1.02128 NH3(s) 1.00355 Glucose(s) 0.659574 Histidine(s) 5.02127659574468 H2O(s) 0.978723404255319 CO2(s) 0.99999999999997 CMP(c) 42 10 - - - - - - 30 CDP(c) CDP(c) MES CDP(c) test that cytosolic CDP can be produced from the minimal exchange set 2.27907 O2(s) 2 Pi(s) 1.26744 NH3(s) 0.955426 Glucose(s) 0.488372 Histidine(s) 0.267442 Valine(s) 6.80232558139535 H2O(s) 1 CO2(s) 0.99999999999997 CDP(c) 38 19 - - - - - - 31 dCDP(c) dCDP(c) MES dCDP(c) test that cytosolic dCDP can be produced from the minimal exchange set 2.21012 O2(s) 2 Pi(s) 0.83463 Glucose(s) 0.984436 Histidine(s) 0.0466926 Valine(s) 5.19455252918288 H2O(s) 2.14785992217899 CO2(s) 0.99999999999997 dCDP(c) 37 22 - - - - - - 28 Xanthine(c) Xanthine(c) MES Xanthine(c) test that cytosolic Xanthine can be produced from the minimal exchange set 6 O2(s) 1 NH3(s) 0.5 Glucose(s) 1 Histidine(s) 6.99999999999999 H2O(s) 4 CO2(s) 0.99999999999997 Xanthine(c) 54 10 - - - - - - 25 Guanine(c) Guanine(c) MES Guanine(c) test that cytosolic Guanine can be produced from the minimal exchange set 6 O2(s) 2 NH3(s) 0.5 Glucose(s) 1 Histidine(s) 8.00000000000002 H2O(s) 4.00000000000001 CO2(s) 0.99999999999997 Guanine(c) 56 9 - - - - - - 25 Deoxyguanosine(c) Deoxyguanosine(c) MES Deoxyguanosine(c) test that cytosolic Deoxyguanosine can be produced from the minimal exchange set 5.5 O2(s) 2 NH3(s) 1.33333 Glucose(s) 1 Histidine(s) 9.00000000000001 H2O(s) 4 CO2(s) 0.99999999999997 Deoxyguanosine(c) 61 11 - - - - - - 24 dGMP(c) dGMP(c) MES dGMP(c) test that cytosolic dGMP can be produced from the minimal exchange set 5.5 O2(s) 1 Pi(s) 2 NH3(s) 1.33333 Glucose(s) 1 Histidine(s) 10 H2O(s) 4 CO2(s) 0.99999999999997 dGMP(c) 61 10 - - - - - - 28 dGDP(c) dGDP(c) MES dGDP(c) test that cytosolic dGDP can be produced from the minimal exchange set 5.5 O2(s) 2 Pi(s) 2 NH3(s) 1.33333 Glucose(s) 1 Histidine(s) 11 H2O(s) 4 CO2(s) 0.99999999999997 dGDP(c) 55 12 - - - - - - 30 GDP-4-dehydro-6-deoxy-D-mannose(c) GDP-4-dehydro-6-deoxy-D-mannose(c) MES GDP-4-dehydro-6-deoxy-D-mannose(c) test that cytosolic GDP-4-dehydro-6-deoxy-D-mannose can be produced from the minimal exchange set 6 O2(s) 2 Pi(s) 2 NH3(s) 2.33333 Glucose(s) 1 Histidine(s) 13 H2O(s) 4 CO2(s) 0.99999999999997 GDP-4-dehydro-6-deoxy-D-mannose(c) 58 11 - - - - - - 31 Amino acid metabolism Alanine(c) Alanine(c) MES Alanine(c) test that cytosolic Alanine can be produced from the minimal exchange set 0.206897 O2(s) 0.689655 NH3(s) 0.448276 Glucose(s) 0.103448 Histidine(s) 0.689655172413794 H2O(s) 0.310344827586207 CO2(s) 0.99999999999997 Alanine(c) 25 11 - - - - - - 21 Arginine(c) Arginine(c) MES Arginine(c) test that cytosolic Arginine can be produced from the minimal exchange set 1.13602 O2(s) 1.23372 NH3(s) 0.766284 Histidine(s) 0.467433 Valine(s) 0.869731800766283 H2O(s) 0.934865900383142 CO2(s) 0.99999999999997 Arginine(c) 17 26 - - - - - - 27 Asparagine(c) Asparagine(c) MES Asparagine(c) test that cytosolic Asparagine can be produced from the minimal exchange set 0.744186 O2(s) 0.883721 NH3(s) 0.313953 Glucose(s) 0.372093 Histidine(s) 0.883720930232559 H2O(s) 0.116279069767442 CO2(s) 0.99999999999997 Asparagine(c) 24 8 - - - - - - 25 Aspartate(c) Aspartate(c) MES Aspartate(c) test that cytosolic Aspartate can be produced from the minimal exchange set 0.666667 O2(s) 0.333333 Glucose(s) 0.333333 Histidine(s) 0.99999999999997 Aspartate(c) 32 10 - - - - - - 16 Cysteine(c) Cysteine(c) MES Cysteine(c) test that cytosolic Cysteine can be produced from the minimal exchange set 6 O2(s) 0.5 Glucose(s) 1 Methionine(s) 5 H2O(s) 5 CO2(s) 0.99999999999997 Cysteine(c) 31 16 - - - - - - 23 Cystine(c) Cystine(c) MES Cystine(c) test that cytosolic Cystine can be produced from the minimal exchange set 12.5 O2(s) 1 Glucose(s) 2 Methionine(s) 11 H2O(s) 10 CO2(s) 0.99999999999997 Cystine(c) 31 15 - - - - - - 22 Glutamate(c) Glutamate(c) MES Glutamate(c) test that cytosolic Glutamate can be produced from the minimal exchange set 0.685427 O2(s) 0.091331 Glucose(s) 0.177725 Phenylalanine(s) 0.0888626 Histidine(s) 0.096564 Valine(s) 0.459123 Threonine(s) 0.0225118483412322 H2O(s) 0.99999999999997 Glutamate(c) 38 25 - - - - - - 27 Glycine(c) Glycine(c) MES Glycine(c) test that cytosolic Glycine can be produced from the minimal exchange set 1.5 O2(s) 1 NH3(s) 0.5 Glucose(s) 2 H2O(s) 1 CO2(s) 0.99999999999997 Glycine(c) 29 7 - - - - - - 21 Glutamine(c) Glutamine(c) MES Glutamine(c) test that cytosolic Glutamine can be produced from the minimal exchange set 0.311966 O2(s) 0.196581 NH3(s) 0.401709 Histidine(s) 0.205128 Valine(s) 0.393162 Threonine(s) 0.00854700854700616 CO2(s) 0.99999999999997 Glutamine(c) 14 18 - - - - - - 23 Proline(c) Proline(c) MES Proline(c) test that cytosolic Proline can be produced from the minimal exchange set 1.05 O2(s) 0.05 Glucose(s) 0.1 Phenylalanine(s) 0.05 Histidine(s) 0.5 Valine(s) 0.25 Threonine(s) 2.45 H2O(s) 0.99999999999997 Proline(c) 31 28 - - - - - - 30 Serine(c) Serine(c) MES Serine(c) test that cytosolic Serine can be produced from the minimal exchange set 0.5 O2(s) 1 NH3(s) 0.5 Glucose(s) 1 H2O(s) 0.99999999999997 Serine(c) 23 3 - - - - - - 17 Tyrosine(c) Tyrosine(c) MES Tyrosine(c) test that cytosolic Tyrosine can be produced from the minimal exchange set 1.01429 O2(s) 0.0857143 Glucose(s) 1 Phenylalanine(s) 0.514285714285714 H2O(s) 0.514285714285714 CO2(s) 0.99999999999997 Tyrosine(c) 24 10 - - - - - - 17 Homocysteine(c) Homocysteine(c) MES Homocysteine(c) test that cytosolic Homocysteine can be produced from the minimal exchange set 1.5 O2(s) 1 Methionine(s) 1 H2O(s) 1 CO2(s) 0.99999999999997 Homocysteine(c) 15 - - - - - - - 12 MetHCys Homocysteine(c) -Methionine(c) -Glucose(s) -Serine(s) +Glycine(s) -O2(s) +CO2(s) =H2O(s) +Urea(s) Homocysteine(c) test that cytosolic Homocysteine can be produced from Methionine serine glucose oxygene while excretion of glycine CO2 urea is allowed 1.5 O2(s) 1 Methionine(c) 1 H2O(s) 1 CO2(s) 0.99999999999997 Homocysteine(c) 15 - - - - - - - 11 beta-Alanine(c) beta-Alanine(c) MES beta-Alanine(c) test that cytosolic beta-Alanine can be produced from the minimal exchange set 0.428571 O2(s) 0.571429 NH3(s) 0.285714 Glucose(s) 0.428571 Threonine(s) 1 H2O(s) 0.428571428571428 CO2(s) 0.99999999999997 beta-Alanine(c) 25 10 - - - - - - 20 Protein synthesis and degradation AlbuminMin Albumin(s) MES r1092(s) test that Albumin can be produced and excreted into the blood from the minimal exchange set 787.149 O2(s) 38 Glucose(s) 60 Lysine(s) 42 Methionine(s) 2 Tryptophan(s) 54 Phenylalanine(s) 64 Leucine(s) 88.3347 Histidine(s) 233.996 Valine(s) 29 Threonine(s) 9 Isoleucine(s) 0.99999999999997 Albumin(s) 500.98406374502 H2O(s) 483.988047808765 CO2(s) 40 36 - - - - - - 39 AlbuminGlc_NoEssHis Albumin(s) -Leucine(s) -Isoleucine(s) -Lysine(s) -Methionine(s) -HC00081(s) -Threonine(s) -Tryptophan(s) -Valine(s) -Glucose(s) +CO2(s) =H2O(s) -O2(s) exclude(s) exclude that albumin can be produced from the amino acid set Leu-Ile-Lys-Met-Phe-Thr-Try-Val (missing essential His) while oxidation of glucose is also allowed - - - - - - - - - AlbuminGlc_NoEssLeu Albumin(s) -HC00133(s) -Isoleucine(s) -Lysine(s) -Methionine(s) -HC00081(s) -Threonine(s) -Tryptophan(s) -Valine(s) -Glucose(s) +CO2(s) =H2O(s) -O2(s) exclude(s) exclude that albumin can be produced from the amino acid set His-Ile-Lys-Met-Phe-Thr-Try-Val (missing essential Leu) while oxidation of glucose is also allowed - - - - - - - - - AlbuminGlc_NoEssIle Albumin(s) -HC00133(s) -Leucine(s) -Lysine(s) -Methionine(s) -HC00081(s) -Threonine(s) -Tryptophan(s) -Valine(s) -Glucose(s) +CO2(s) =H2O(s) -O2(s) exclude(s) exclude that albumin can be produced from the amino acid set His-Leu-Lys-Met-Phe-Thr-Try-Val (missing essential Ile) while oxidation of glucose is also allowed - - - - - - - - - AlbuminGlc_NoEssLys Albumin(s) -HC00133(s) -Leucine(s) -Isoleucine(s) -Methionine(s) -HC00081(s) -Threonine(s) -Tryptophan(s) -Valine(s) -Glucose(s) +CO2(s) =H2O(s) -O2(s) exclude(s) exclude that albumin can be produced from the amino acid set His-Leu-Ile-Met-Phe-Thr-Try-Val (missing essential Lys) while oxidation of glucose is also allowed - - - - - - - - - AlbuminGlc_NoEssMet Albumin(s) -HC00133(s) -Leucine(s) -Isoleucine(s) -Lysine(s) -HC00081(s) -Threonine(s) -Tryptophan(s) -Valine(s) -Glucose(s) +CO2(s) =H2O(s) -O2(s) exclude(s) exclude that albumin can be produced from the amino acid set His-Leu-Ile-Lys-Phe-Thr-Try-Val (missing essential Met) while oxidation of glucose is also allowed - - - - - - - - - AlbuminGlc_NoEssPhe Albumin(s) -HC00133(s) -Leucine(s) -Isoleucine(s) -Lysine(s) -Methionine(s) -Threonine(s) -Tryptophan(s) -Valine(s) -Glucose(s) +CO2(s) =H2O(s) -O2(s) exclude(s) exclude that albumin can be produced from the amino acid set His-Leu-Ile-Lys-Met-Thr-Try-Val (missing essential Phe) while oxidation of glucose is also allowed - - - - - - - - - AlbuminGlc_NoEssThr Albumin(s) -HC00133(s) -Leucine(s) -Isoleucine(s) -Lysine(s) -Methionine(s) -HC00081(s) -Tryptophan(s) -Valine(s) -Glucose(s) +CO2(s) =H2O(s) -O2(s) exclude(s) exclude that albumin can be produced from the amino acid set His-Leu-Ile-Lys-Met-Phe-Try-Val (missing essential Thr) while oxidation of glucose is also allowed - - - - - - - - - AlbuminGlc_NoEssTry Albumin(s) -HC00133(s) -Leucine(s) -Isoleucine(s) -Lysine(s) -Methionine(s) -HC00081(s) -Threonine(s) -Valine(s) -Glucose(s) +CO2(s) =H2O(s) -O2(s) exclude(s) exclude that albumin can be produced from the amino acid set His-Leu-Ile-Lys-Met-Phe-Thr-Val (missing essential Try) while oxidation of glucose is also allowed - - - - - - - - - AlbuminGlc_NoEssVal Albumin(s) -HC00133(s) -Leucine(s) -Isoleucine(s) -Lysine(s) -Methionine(s) -HC00081(s) -Threonine(s) -Tryptophan(s) -Glucose(s) +CO2(s) =H2O(s) -O2(s) exclude(s) exclude that albumin can be produced from the amino acid set His-Leu-Ile-Lys-Met-Phe-Thr-Try (missing essential Val) while oxidation of glucose is also allowed - - - - - - - - - AntichymotrypsinMin HC00002(s) MES HC00002(s) test that Antichymotrypsin can be produced and excreted into the blood from the minimal exchange set 531.237 O2(s) 9.96241 NH3(s) 24.5 Glucose(s) 26 Lysine(s) 17 Methionine(s) 3 Tryptophan(s) 34 Phenylalanine(s) 59 Leucine(s) 54.0376 Histidine(s) 164.925 Valine(s) 29 Threonine(s) 20 Isoleucine(s) 0.99999999999997 Antichymotrypsin(s) 350.699248120301 H2O(s) 321.84962406015 CO2(s) 40 35 - - - - - - 40 AntitrypsinMin HC00003(s) MES HC00003(s) test that Antitrypsin can be produced and excreted into the blood from the minimal exchange set 515.03 O2(s) 26 Glucose(s) 34 Lysine(s) 13 Methionine(s) 3 Tryptophan(s) 33 Phenylalanine(s) 51 Leucine(s) 52.2669 Histidine(s) 161.199 Valine(s) 30 Threonine(s) 20 Isoleucine(s) 0.99999999999997 Antitrypsin(s) 347.796812749004 H2O(s) 308.597609561753 CO2(s) 40 36 - - - - - - 39 ApoA1Min HC00004(s) MES HC00004(s) test that ApoA1 can be produced and excreted into the blood from the minimal exchange set 339.936 O2(s) 13.5 Glucose(s) 22 Lysine(s) 4 Methionine(s) 5 Tryptophan(s) 15 Phenylalanine(s) 41 Leucine(s) 46.6972 Histidine(s) 114.908 Valine(s) 12 Threonine(s) 0.99999999999997 ApoA1(s) 199.633466135459 H2O(s) 204.725099601594 CO2(s) 36 31 - - - - - - 34 ApoB100Min HC00005(r) MES HC00005(r) test that ApoB100 can be produced in the ER from the minimal exchange set 5823.66 O2(s) 239.023 NH3(s) 312 Glucose(s) 357 Lysine(s) 104 Methionine(s) 37 Tryptophan(s) 375 Phenylalanine(s) 533 Leucine(s) 577.977 Histidine(s) 1754.05 Valine(s) 300 Threonine(s) 285 Isoleucine(s) 0.99999999999997 ApoB100(r) 4001.18045112782 H2O(s) 3480.09022556391 CO2(s) 40 35 - - - - - - 40 ApoC1Min HC00006(c) MES HC00006(c) test that cytosolic ApoC1 can be produced from the minimal exchange set 101.914 O2(s) 6 Glucose(s) 9 Lysine(s) 2 Methionine(s) 1 Tryptophan(s) 4 Phenylalanine(s) 12 Leucine(s) 9.96813 Histidine(s) 34.0956 Valine(s) 3 Threonine(s) 4 Isoleucine(s) 0.99999999999997 ApoC1(c) 66.3824701195217 H2O(s) 64.2868525896414 CO2(s) 35 30 - - - - - - 35 ApoC2Min HC00007(c) MES HC00007(c) test that cytosolic ApoC2 can be produced from the minimal exchange set 126.948 O2(s) 7 Glucose(s) 6 Lysine(s) 3 Methionine(s) 1 Tryptophan(s) 9 Phenylalanine(s) 15 Leucine(s) 10.004 Histidine(s) 40.988 Valine(s) 10 Threonine(s) 1 Isoleucine(s) 0.99999999999997 ApoC2(c) 84.9521912350598 H2O(s) 76.9641434262948 CO2(s) 35 30 - - - - - - 37 ApoC3Min HC00008(c) MES HC00008(c) test that cytosolic ApoC3 can be produced from the minimal exchange set 123.763 O2(s) 2.89474 NH3(s) 7.5 Glucose(s) 6 Lysine(s) 3 Methionine(s) 3 Tryptophan(s) 6 Phenylalanine(s) 11 Leucine(s) 13.1053 Histidine(s) 42.7895 Valine(s) 5 Threonine(s) 0.99999999999997 ApoC3(c) 75.1578947368421 H2O(s) 77.5789473684211 CO2(s) 34 29 - - - - - - 36 ApoEMin HC00009(c) MES HC00009(c) test that cytosolic ApoE can be produced from the minimal exchange set 411.769 O2(s) 17 Glucose(s) 13 Lysine(s) 10 Methionine(s) 8 Tryptophan(s) 8 Phenylalanine(s) 41 Leucine(s) 73.4024 Histidine(s) 141.793 Valine(s) 12 Threonine(s) 2 Isoleucine(s) 0.99999999999997 ApoE(c) 204.171314741036 H2O(s) 276.378486055777 CO2(s) 40 37 - - - - - - 37 PlasminogenMin HC01942(s) MES HC01942(s) test that Plasminogen can be produced and excreted into the blood from the minimal exchange set 1104.89 O2(s) 48.8421 NH3(s) 83 Glucose(s) 49 Lysine(s) 59 Methionine(s) 19 Tryptophan(s) 51 Phenylalanine(s) 48 Leucine(s) 140.158 Histidine(s) 276.684 Valine(s) 61 Threonine(s) 22 Isoleucine(s) 807.736842105263 H2O(s) 695.368421052631 CO2(s) 0.99999999999997 Plasminogen(s) 40 36 - - - - - - 37 ProthrombinMin HC01943(s) MES HC01943(s) test that Prothrombin can be produced and excreted into the blood from the minimal exchange set 839.105 O2(s) 44.7293 NH3(s) 56.5 Glucose(s) 29 Lysine(s) 35 Methionine(s) 14 Tryptophan(s) 42 Phenylalanine(s) 51 Leucine(s) 110.271 Histidine(s) 226.459 Valine(s) 36 Threonine(s) 22 Isoleucine(s) 562.834586466165 H2O(s) 529.917293233083 CO2(s) 0.99999999999997 Prothrombin(s) 40 35 - - - - - - 40 ApoTransferinMin HC01944(s) MES HC01944(s) test that ApoTransferin can be produced and excreted into the blood from the minimal exchange set 932.921 O2(s) 81.7744 NH3(s) 66.5 Glucose(s) 58 Lysine(s) 50 Methionine(s) 8 Tryptophan(s) 54 Phenylalanine(s) 65 Leucine(s) 84.2256 Histidine(s) 253.549 Valine(s) 30 Threonine(s) 15 Isoleucine(s) 702.195488721804 H2O(s) 555.097744360902 CO2(s) 0.99999999999997 ApoTransferin(s) 40 35 - - - - - - 39 HaptoglobinMin HC01939(s) MES HC01939(s) test that Haptoglobin can be produced and excreted into the blood from the minimal exchange set 530.211 O2(s) 11.8872 NH3(s) 30.5 Glucose(s) 35 Lysine(s) 17 Methionine(s) 8 Tryptophan(s) 29 Phenylalanine(s) 31 Leucine(s) 55.1128 Histidine(s) 159.774 Valine(s) 22 Threonine(s) 18 Isoleucine(s) 365.097744360903 H2O(s) 319.548872180451 CO2(s) 0.99999999999997 Haptoglobin(s) 40 36 - - - - - - 37 Apo-ACPMin Apo-ACP(c) MES Apo-ACP(c) test that cytosolic Apo-ACP can be produced from the minimal exchange set 161.421 O2(s) 2.48872 NH3(s) 8 Glucose(s) 4 Lysine(s) 7 Methionine(s) 7 Phenylalanine(s) 20 Leucine(s) 19.5113 Histidine(s) 51.9774 Valine(s) 6 Threonine(s) 4 Isoleucine(s) 107.90977443609 H2O(s) 103.954887218045 CO2(s) 0.99999999999997 Apo-ACP(c) 40 36 - - - - - - 35 Apo-ACPMin(m) mitoApo-ACP(m) MES mitoApo-ACP(m) test that mitochondrial Apo-ACP can be produced from the minimal exchange set 83.1667 O2(s) 2.75 Glucose(s) 7 Lysine(s) 6 Methionine(s) 7 Phenylalanine(s) 10 Leucine(s) 7.25641 Histidine(s) 35.2308 Valine(s) 1 Threonine(s) 8 Isoleucine(s) 54.4230769230769 H2O(s) 31.1923076923077 CO2(s) 0.99999999999997 mitoApo-ACP(m) 36 42 - - - - - - 50 CoAMin HC00020(c) MES HC00020(c) test that cytosolic CoA can be produced from the minimal exchange set 6.5 O2(s) 3 Pi(s) 5 NH3(s) 1.83333 Glucose(s) 1 Methionine(s) 1 Pantothenate(s) 19 H2O(s) 0.99999999999997 CoA(c) 4 CO2(s) 53 21 - - - - - - 32 Thioredoxin(c) Thioredoxin(c) MES Thioredoxin(c) test that cytosolic Thioredoxin can be produced from the minimal exchange set 129.333 O2(s) 8.5 Glucose(s) 12 Lysine(s) 8 Methionine(s) 1 Tryptophan(s) 10 Phenylalanine(s) 6 Leucine(s) 9.70518 Histidine(s) 40.8845 Valine(s) 4 Threonine(s) 4 Isoleucine(s) 85.5378486055779 H2O(s) 77.6533864541833 CO2(s) 0.99999999999997 Thioredoxin(c) 37 34 - - - - - - 34 mitoThioredoxin mitoThioredoxin(m) MES mitoThioredoxin(m) test that mitochondrial Thioredoxin can be produced from the minimal exchange set 211.237 O2(s) 2.39098 NH3(s) 10.5 Glucose(s) 11 Lysine(s) 7 Methionine(s) 2 Tryptophan(s) 8 Phenylalanine(s) 15 Leucine(s) 25.609 Histidine(s) 69.782 Valine(s) 12 Threonine(s) 9 Isoleucine(s) 145.127819548872 H2O(s) 133.563909774436 CO2(s) 0.99999999999997 mitoThioredoxin(m) 40 34 - - - - - - 41 Glycogenin(c) Glycogenin(c) MES Glycogenin(c) test that cytosolic Glycogenin can be produced from the minimal exchange set 450.316 O2(s) 34.3308 NH3(s) 27.5 Glucose(s) 18 Lysine(s) 14 Methionine(s) 7 Tryptophan(s) 33 Phenylalanine(s) 39 Leucine(s) 35.6692 Histidine(s) 140.662 Valine(s) 25 Threonine(s) 12 Isoleucine(s) 339.646616541353 H2O(s) 261.323308270677 CO2(s) 0.99999999999997 Glycogenin(c) 41 35 - - - - - - 37 Glycogenin-G8(c) Glycogenin-G8(c) MES Glycogenin-G8(c) test that cytosolic Glycogen can produced from the minimal exchange set 453.684 O2(s) 34.812 NH3(s) 35.5 Glucose(s) 18 Lysine(s) 14 Methionine(s) 7 Tryptophan(s) 33 Phenylalanine(s) 39 Leucine(s) 35.188 Histidine(s) 141.624 Valine(s) 25 Threonine(s) 12 Isoleucine(s) 351.496240601504 H2O(s) 263.248120300752 CO2(s) 0.99999999999997 Glycogenin-G8(c) 44 35 - - - - - - 38 Glycogenin-G11(c) Glycogenin-G11(c) MES Glycogenin-G11(c) test that cytosolic Glycogen can produced from the minimal exchange set 454.947 O2(s) 34.9925 NH3(s) 38.5 Glucose(s) 18 Lysine(s) 14 Methionine(s) 7 Tryptophan(s) 33 Phenylalanine(s) 39 Leucine(s) 35.0075 Histidine(s) 141.985 Valine(s) 25 Threonine(s) 12 Isoleucine(s) 355.93984962406 H2O(s) 263.96992481203 CO2(s) 0.99999999999997 Glycogenin-G11(c) 44 35 - - - - - - 40 Glycogenin-G4G7(c) Glycogenin-G4G7(c) MES Glycogenin-G4G7(c) test that cytosolic Glycogen can produced from the minimal exchange set 454.947 O2(s) 34.9925 NH3(s) 38.5 Glucose(s) 18 Lysine(s) 14 Methionine(s) 7 Tryptophan(s) 33 Phenylalanine(s) 39 Leucine(s) 35.0075 Histidine(s) 141.985 Valine(s) 25 Threonine(s) 12 Isoleucine(s) 355.93984962406 H2O(s) 263.96992481203 CO2(s) 0.99999999999997 Glycogenin-G4G7(c) 45 35 - - - - - - 40 Glycogenin-G4G4(c) Glycogenin-G4G4(c) MES Glycogenin-G4G4(c) test that cytosolic Glycogen can produced from the minimal exchange set 454.316 O2(s) 34.9023 NH3(s) 35.5 Glucose(s) 18 Lysine(s) 14 Methionine(s) 7 Tryptophan(s) 33 Phenylalanine(s) 39 Leucine(s) 35.0977 Histidine(s) 141.805 Valine(s) 25 Threonine(s) 12 Isoleucine(s) 352.218045112782 H2O(s) 263.609022556391 CO2(s) 0.99999999999997 Glycogenin-G4G4(c) 46 35 - - - - - - 40 Glycogenin-G7G1(c) Glycogenin-G7G1(c) MES Glycogenin-G7G1(c) test that cytosolic Glycogen can produced from the minimal exchange set 454.316 O2(s) 34.9023 NH3(s) 35.5 Glucose(s) 18 Lysine(s) 14 Methionine(s) 7 Tryptophan(s) 33 Phenylalanine(s) 39 Leucine(s) 35.0977 Histidine(s) 141.805 Valine(s) 25 Threonine(s) 12 Isoleucine(s) 352.218045112782 H2O(s) 263.609022556391 CO2(s) 0.99999999999997 Glycogenin-G7G1(c) 47 35 - - - - - - 40 Glycogenin-G7(c) Glycogenin-G7(c) MES Glycogenin-G7(c) test that cytosolic Glycogen can produced from the minimal exchange set 454.316 O2(s) 34.9023 NH3(s) 34.5 Glucose(s) 18 Lysine(s) 14 Methionine(s) 7 Tryptophan(s) 33 Phenylalanine(s) 39 Leucine(s) 35.0977 Histidine(s) 141.805 Valine(s) 25 Threonine(s) 12 Isoleucine(s) 351.218045112782 H2O(s) 263.609022556391 CO2(s) 0.99999999999997 Glycogenin-G7(c) 49 35 - - - - - - 38 Albumin(s)_waste -1 Albumin(s) DES Albumin(s) test that Albumin can be degraded using the digestion target set 1 Albumin(s) 158.139 H2O(s) 546.823 O2(s) 44.1426 Tryptophan(s) 542.720293961396 CO2(s) 124.142553568266 NH3(s) 158.011672864648 Glucose(s) 60 Lysine(s) 42 Methionine(s) 35 Phenylalanine(s) 197.571276784133 Urea(s) 64 Leucine(s) 16 Histidine(s) 43 Valine(s) 1.85744643173366 Cholesterol(b) 29 Threonine(s) 9 Isoleucine(s) 4.56596422879416 Palmitolate(s) 96 28 18 6 - - - - 57 Antichymotrypsin(s)_waste -1 Antichymotrypsin(s) DES Antichymotrypsin(s) test that Antichymotrypsin can be degraded using the digestion target set 1 Antichymotrypsin(s) 74.6479 H2O(s) 293.171 O2(s) 14.6845 Tryptophan(s) 313.386314655172 CO2(s) 99.6845366379309 NH3(s) 91.7175601652297 Glucose(s) 26 Lysine(s) 16.9999999999999 Methionine(s) 25 Phenylalanine(s) 115.342268318966 Urea(s) 59 Leucine(s) 9 Histidine(s) 24 Valine(s) 1.31546336206898 Cholesterol(b) 29 Threonine(s) 20 Isoleucine(s) 3.8111530172414 Palmitolate(s) 94 32 19 6 - - - - 56 Antitrypsin(s)_waste -1 Antitrypsin(s) DES Antitrypsin(s) test that Antitrypsin can be degraded using the digestion target set 1 Antitrypsin(s) 123.288 H2O(s) 306.104 O2(s) 23.5032 Tryptophan(s) 324.686791784703 CO2(s) 112.503186968839 NH3(s) 102.210812086874 Glucose(s) 34 Lysine(s) 13 Methionine(s) 27 Phenylalanine(s) 99.2515934844193 Urea(s) 51 Leucine(s) 13 Histidine(s) 27 Valine(s) 0.496813031161473 Cholesterol(b) 30 Threonine(s) 20 Isoleucine(s) 3.05736543909348 Palmitolate(s) 93 29 19 6 - - - - 59 ApoA1(s)_waste -1 ApoA1(s) DES ApoA1(s) test that ApoA1 can be degraded using the digestion target set 1 ApoA1(s) 195.25 H2O(s) 134.625 O2(s) 5 Histidine(s) 209 CO2(s) 228 NH3(s) 82.5 Glucose(s) 22 Lysine(s) 4 Methionine(s) 5 Tryptophan(s) 8 Phenylalanine(s) 17 Urea(s) 41 Leucine(s) 15 Valine(s) 12 Threonine(s) 1.75 Palmitolate(s) 39.5 ATP-energy(m) 75 16 1 - - - - - 39 Fibrinogen(s)_waste -1 Fibrinogen(s) DES Fibrinogen(s) test that Fibrinogen can be degraded using the digestion target set 1259.65 H2O(s) 3001.16 O2(s) 237.653 Tryptophan(s) 1 Fibrinogen(s) 3039.76118974751 CO2(s) 1085.65316564652 NH3(s) 908.725950809741 Glucose(s) 154 Lysine(s) 96 Methionine(s) 98 Phenylalanine(s) 894.826582823259 Urea(s) 166 Leucine(s) 62 Histidine(s) 122 Valine(s) 12.3468343534813 Cholesterol(b) 182 Threonine(s) 104 Isoleucine(s) 13.117301071153 Palmitolate(s) 93 32 18 6 - - - - 59 Haptoglobin(s)_waste -1 Haptoglobin(s) DES Haptoglobin(s) test that Haptoglobin can be degraded using the digestion target set 157.772 H2O(s) 436.492 O2(s) 32.8288 Tryptophan(s) 1 Haptoglobin(s) 449.597485390472 CO2(s) 127.828758632902 NH3(s) 116.633079511245 Glucose(s) 35 Lysine(s) 16.9999999999998 Methionine(s) 8 Phenylalanine(s) 118.414379316451 Urea(s) 31 Leucine(s) 13 Histidine(s) 36 Valine(s) 2.17124136709757 Cholesterol(b) 22 Threonine(s) 18 Isoleucine(s) 2.91765539224368 Palmitolate(s) 94 29 19 6 - - - - 59 Plasminogen(s)_waste -1 Plasminogen(s) DES Plasminogen(s) test that Plasminogen can be degraded using the digestion target set 486.558 H2O(s) 974.042 O2(s) 87.4415 Tryptophan(s) 1 Plasminogen(s) 965.278901734105 CO2(s) 295.44151649099 NH3(s) 279.755355321319 Glucose(s) 49 Lysine(s) 59 Methionine(s) 21 Phenylalanine(s) 286.720758245495 Urea(s) 48 Leucine(s) 24 Histidine(s) 48 Valine(s) 3.55848350901053 Cholesterol(b) 61 Threonine(s) 22 Isoleucine(s) 3.57786467188043 Palmitolate(s) 96 29 19 6 - - - - 58 Prothrombin(s)_waste -1 Prothrombin(s) DES Prothrombin(s) test that Prothrombin can be degraded using the digestion target set 296.747 H2O(s) 719.267 O2(s) 57.7466 Tryptophan(s) 1 Prothrombin(s) 694.881503442999 CO2(s) 209.746604820199 NH3(s) 208.2848563823 Glucose(s) 29 Lysine(s) 35 Methionine(s) 21 Phenylalanine(s) 240.373302410099 Urea(s) 51 Leucine(s) 13 Histidine(s) 37 Valine(s) 3.25339517980107 Cholesterol(b) 36 Threonine(s) 22 Isoleucine(s) 2.83793993879112 Palmitolate(s) 94 31 19 6 - - - - 58 ApoTransferin(s)_waste -1 ApoTransferin(s) DES ApoTransferin(s) test that ApoTransferin can be degraded using the digestion target set 327.265 H2O(s) 806.279 O2(s) 81.2649 Tryptophan(s) 1 ApoTransferin(s) 795.595495409334 CO2(s) 233.264943573068 NH3(s) 222.952656768044 Glucose(s) 58 Lysine(s) 50 Methionine(s) 28 Phenylalanine(s) 227.132471786534 Urea(s) 65 Leucine(s) 19 Histidine(s) 48 Valine(s) 2.7350564269319 Cholesterol(b) 30 Threonine(s) 15 Isoleucine(s) 2.78899674827855 Palmitolate(s) 93 31 19 6 - - - - 60 ApoB100(l) -1 ApoB100(l) DES ApoB100(l) test that ApoB100 can be degraded using the digestion target set 1 ApoB100(l) 1077.3 H2O(s) 3442.08 O2(s) 180.525 Tryptophan(s) 3711.49433427767 CO2(s) 1293.52549575071 NH3(s) 1075.81149669495 Glucose(s) 357 Lysine(s) 104 Methionine(s) 224 Phenylalanine(s) 1211.26274787535 Urea(s) 533 Leucine(s) 115 Histidine(s) 252 Valine(s) 14.4745042493255 Cholesterol(b) 300 Threonine(s) 285 Isoleucine(s) 41.4589235126982 Palmitolate(s) 92 29 19 6 1 - - - 81 Glycogenin(c)_waste -1 Glycogenin(c) DES Glycogenin(c) test that cytosolic Glycogenin can be degraded 92.8422 H2O(s) 292.671 O2(s) 15.711 Tryptophan(s) 1 Glycogenin(c) 310.469851248451 CO2(s) 97.710996989552 NH3(s) 84.9875671447967 Glucose(s) 18 Lysine(s) 14 Methionine(s) 20 Phenylalanine(s) 93.855498494776 Urea(s) 39 Leucine(s) 9 Histidine(s) 28 Valine(s) 1.28900301044803 Cholesterol(b) 25 Threonine(s) 12 Isoleucine(s) 2.79794581193554 Palmitolate(s) 94 29 19 6 - - - - 57 Glycogenin-G8(c)_waste -1 Glycogenin-G8(c) DES Glycogenin-G8(c) test that cytosolic Glycogen can degraded 100.842 H2O(s) 292.671 O2(s) 15.711 Tryptophan(s) 1 Glycogenin-G8(c) 310.46985124845 CO2(s) 97.7109969895519 NH3(s) 92.9875671447965 Glucose(s) 18 Lysine(s) 13.9999999999999 Methionine(s) 20 Phenylalanine(s) 93.8554984947759 Urea(s) 39 Leucine(s) 9 Histidine(s) 28 Valine(s) 1.28900301044802 Cholesterol(b) 25 Threonine(s) 12 Isoleucine(s) 2.79794581193557 Palmitolate(s) 105 28 20 6 - - - - 57 Glycogenin-G11(c)_waste -1 Glycogenin-G11(c) DES Glycogenin-G11(c) test that cytosolic Glycogen can degraded 103.842 H2O(s) 292.671 O2(s) 15.711 Tryptophan(s) 1 Glycogenin-G11(c) 310.46985124845 CO2(s) 97.7109969895519 NH3(s) 95.9875671447966 Glucose(s) 18 Lysine(s) 14 Methionine(s) 20 Phenylalanine(s) 93.855498494776 Urea(s) 39 Leucine(s) 9 Histidine(s) 28 Valine(s) 1.28900301044802 Cholesterol(b) 25 Threonine(s) 12 Isoleucine(s) 2.79794581193556 Palmitolate(s) 102 28 19 6 - - - - 55 Glycogenin-G4G7(c)_waste -1 Glycogenin-G4G7(c) DES Glycogenin-G4G7(c) test that cytosolic Glycogen can degraded 103.842 H2O(s) 292.671 O2(s) 15.711 Tryptophan(s) 1 Glycogenin-G4G7(c) 310.46985124845 CO2(s) 97.7109969895519 NH3(s) 95.9875671447966 Glucose(s) 18 Lysine(s) 14 Methionine(s) 20 Phenylalanine(s) 93.855498494776 Urea(s) 39 Leucine(s) 9 Histidine(s) 28 Valine(s) 1.28900301044802 Cholesterol(b) 25 Threonine(s) 12 Isoleucine(s) 2.79794581193556 Palmitolate(s) 100 29 19 6 - - - - 55 Glycogenin-G4G4(c)_waste -1 Glycogenin-G4G4(c) DES Glycogenin-G4G4(c) test that cytosolic Glycogen can degraded 100.842 H2O(s) 292.671 O2(s) 15.711 Tryptophan(s) 1 Glycogenin-G4G4(c) 310.46985124845 CO2(s) 97.710996989552 NH3(s) 92.9875671447966 Glucose(s) 18 Lysine(s) 14 Methionine(s) 20 Phenylalanine(s) 93.855498494776 Urea(s) 39 Leucine(s) 9 Histidine(s) 28 Valine(s) 1.28900301044803 Cholesterol(b) 25 Threonine(s) 12 Isoleucine(s) 2.79794581193554 Palmitolate(s) 98 29 20 6 - - - - 56 Glycogenin-G7G1(c)_waste -1 Glycogenin-G7G1(c) DES Glycogenin-G7G1(c) test that cytosolic Glycogen can degraded 100.842 H2O(s) 292.671 O2(s) 15.711 Tryptophan(s) 1 Glycogenin-G7G1(c) 310.46985124845 CO2(s) 97.710996989552 NH3(s) 92.9875671447966 Glucose(s) 18 Lysine(s) 14 Methionine(s) 20 Phenylalanine(s) 93.855498494776 Urea(s) 39 Leucine(s) 9 Histidine(s) 28 Valine(s) 1.28900301044803 Cholesterol(b) 25 Threonine(s) 12 Isoleucine(s) 2.79794581193554 Palmitolate(s) 97 29 20 6 - - - - 56 Glycogenin-G7(c)_waste -1 Glycogenin-G7(c) DES Glycogenin-G7(c) test that cytosolic Glycogen can degraded 99.8422 H2O(s) 292.671 O2(s) 15.711 Tryptophan(s) 1 Glycogenin-G7(c) 310.469851248451 CO2(s) 97.7109969895521 NH3(s) 91.9875671447967 Glucose(s) 18 Lysine(s) 14.0000000000001 Methionine(s) 20 Phenylalanine(s) 93.855498494776 Urea(s) 39 Leucine(s) 9 Histidine(s) 28 Valine(s) 1.28900301044803 Cholesterol(b) 25 Threonine(s) 12 Isoleucine(s) 2.79794581193567 Palmitolate(s) 96 30 19 6 - - - - 55 Lipid and lipoprotein metabolism VLDL(s) VLDL(s) MES VLDL(s) synthesis of VLDL particle from minimal exchange set and excretion into blood 35702 O2(s) 3271 Pi(s) 8772.98 Glucose(s) 448 Lysine(s) 174 Methionine(s) 93 Tryptophan(s) 431 Phenylalanine(s) 3085 Choline(c) 820 Leucine(s) 129 Histidine(s) 6629 Valine(s) 384 Threonine(s) 185 Ethanolamine(c) 6884.2 Arachidonate(s) 299 Isoleucine(s) 4040.5 Linoleate(s) 33418.4 Palmitolate(s) 63938.1897445342 H2O(s) 43685.908681839 CO2(s) 0.99999999999997 VLDL(s) 112 70 33 6 - - - - 77 HDL(s) HDL(s) MES HDL(s) synthesis of HDL particle from minimal exchange set and excretion into blood 1037.73 O2(s) 220 Pi(s) 124.5 Glucose(s) 44 Lysine(s) 8 Methionine(s) 10 Tryptophan(s) 30 Phenylalanine(s) 165 Choline(c) 82 Leucine(s) 82.7462 Histidine(s) 311.761 Valine(s) 24 Threonine(s) 80 Ethanolamine(c) 95.7027 Arachidonate(s) 4.31047 Linoleate(s) 387.833 Palmitolate(s) 1353.28419741913 H2O(s) 909.439755285095 CO2(s) 0.99999999999997 HDL(s) 78 68 18 6 - - - - 65 Cardiolipin(m) CL-pool(m) MES CL-pool(m) synthesis of mitochondrial Cardiolipin from minimal exchange set 3.28368 O2(s) 1 Pi(s) 2.31716 Glucose(s) 2.99695 Linoleate(s) 1.21557 Palmitolate(s) 7.98892917572884 H2O(s) 4.45322697606914 CO2(s) 0.99999999999997 CL-pool(m) 34 53 - - - - - - 26 Farnesyl-PP(p) Farnesyl-PP(p) MES Farnesyl-PP(p) synthesis of farnesyl diphosphate in the peroxysome from minimal exchange set 4.5487 O2(s) 2 Pi(s) 0.62987 Glucose(s) 0.967532 Palmitolate(s) 7.29220779220778 H2O(s) 4.25974025974025 CO2(s) 0.99999999999997 Farnesyl-PP(p) 23 33 - 6 - - - - 28 Glycerol Glycerol(c) MES Glycerol(c) synthesis of glycerol in the cytosol 0.952381 O2(s) 0.742063 Glucose(s) 0.452380952380952 H2O(s) 1.45238095238095 CO2(s) 0.99999999999997 Glycerol(c) 45 8 - - - - - - 16 LacCer-pool(r) LacCer-pool(r) MES LacCer-pool(r) synthesis of Lactosyl ceramide-pool in the ER from the minimal exchange set 1.55155 O2(s) 0.608203 NH3(s) 2.5 Glucose(s) 0.130599 Histidine(s) 0.016661 Arachidonate(s) 0.0306018 Linoleate(s) 2.03381 Palmitolate(s) 4.01344969587064 H2O(s) 2.75650482888622 CO2(s) 0.99999999999997 LacCer-pool(r) 40 50 2 - - - - - 34 Palmitate(c) Palmitate(c) MES Palmitate(c) synthesis of cytosolic palmitate from the minimal exchange set 0.775 H2O(s) 0.05 Phenylalanine(s) 1 Palmitolate(s) 0.425 CO2(s) 0.025 Urea(s) 0.99999999999997 Palmitate(c) 38 18 - - - - - - 23 Stearate(c) Stearate(c) MES Stearate(c) synthesis of cytosolic stearate from the minimal exchange set 0.442851 H2O(s) 0.335724 O2(s) 1.13272 Palmitolate(s) 0.689868751871179 CO2(s) 0.99999999999997 Stearate(c) 65 49 - - - - - - 22 Oleate(c) Oleate(c) MES Oleate(c) synthesis of cytosolic oleate from the minimal exchange set 1.45602 O2(s) 1.1594 Palmitolate(s) 0.97068198119255 H2O(s) 1.13008081868885 CO2(s) 0.99999999999997 Oleate(c) 57 49 - - - - - - 23 Bile excretion PC-bile HC02080(b) MES HC02080(b) pooled PC in bile specific FA content, synthesis from minimal exchange set and excretion into bile 1.23009 O2(s) 1 Pi(s) 0.544373 Glucose(s) 1 Choline(c) 0.112642 Arachidonate(s) 0.655682 Linoleate(s) 1.34878 Palmitolate(s) 3.61768148248263 H2O(s) 1.67147284124776 CO2(s) 0.99999999999997 Bile-PC-pool(b) 36 48 - - - - - - 26 PS-bile HC02006(b) MES HC02006(b) pooled PS, synthesis from minimal exchange set and excretion into bile 1.37885 O2(s) 1 Pi(s) 0.784376 NH3(s) 0.892188 Glucose(s) 0.215624 Ethanolamine(c) 0.581989 Arachidonate(s) 0.290235 Linoleate(s) 1.29432 Palmitolate(s) 4.1241653534227 H2O(s) 1.26768664646249 CO2(s) 0.99999999999997 PS-VLDL-pool(b) 82 50 - - - - - - 34 PE-bile HC02002(b) MES HC02002(b) pooled PE, synthesis from minimal exchange set and excretion into bile 1.50463 O2(s) 1 Pi(s) 0.5 Glucose(s) 1 Ethanolamine(c) 0.596133 Arachidonate(s) 0.357143 Linoleate(s) 1.22038 Palmitolate(s) 3.75102722793378 H2O(s) 1.80277223671424 CO2(s) 0.99999999999997 PE-VLDL-pool(b) 76 49 - - - - - - 30 SM-bile HC02007(b) MES HC02007(b) pooled SM, synthesis from minimal exchange set and excretion into bile 1.55155 O2(s) 1 Pi(s) 0.608203 NH3(s) 0.5 Glucose(s) 1 Choline(c) 0.130599 Histidine(s) 0.016661 Arachidonate(s) 0.0306018 Linoleate(s) 2.03381 Palmitolate(s) 4.01344969587064 H2O(s) 2.75650482888623 CO2(s) 0.99999999999997 SM-pool(b) 39 50 1 - - - - - 38 Glycocholate(b) Glycocholate(b) MES Glycocholate(b) Glycocholate synthesis from minimal exchange set and excretion into bile 25.5155 O2(s) 2.28169 Glucose(s) 1.56668 Phenylalanine(s) 0.0739154 Leucine(s) 1.29352 Palmitolate(s) 19.0495447241564 H2O(s) 22.6098018211034 CO2(s) 0.320299946438138 Urea(s) 0.99999999999997 Glycocholate(b) 56 49 21 13 - - - - 50 Glycochenodeoxycholate(b) Glycochenodeoxycholate(b) MES Glycochenodeoxycholate(b) Glycochenodeoxycholate synthesis from minimal exchange set and excretion into bile 23.2455 O2(s) 2.30604 Glucose(s) 1.32368 Phenylalanine(s) 1.38544 Palmitolate(s) 17.0744416873449 H2O(s) 21.7546181417149 CO2(s) 0.161841742486904 Urea(s) 0.99999999999997 Glycochenodeoxycholate(b) 54 44 20 8 - - - - 49 Taurocholate(b) Taurocholate(b) MES Taurocholate(b) Taurocholate synthesis from minimal exchange set and excretion into bile 29.4404 O2(s) 1.83333 Glucose(s) 1 Methionine(s) 2.25467 Phenylalanine(s) 0.254673 Leucine(s) 0.954829 Palmitolate(s) 18.8691588785047 H2O(s) 25.8426791277259 CO2(s) 1.25467289719626 Urea(s) 0.99999999999997 Taurocholate(b) 60 51 21 13 - - - - 53 Chenodiol(b) Chenodiol(b) MES Chenodiol(b) Chenodiol synthesis from minimal exchange set and excretion into bile 20.395 O2(s) 2.90055 Glucose(s) 0.491745 Phenylalanine(s) 0.491745 Leucine(s) 1.23939 Palmitolate(s) 17.9115566037736 H2O(s) 20.1179245283019 CO2(s) 0.491745283018868 Urea(s) 0.99999999999997 Chenodiol(b) 47 49 20 8 - - - - 48 Cholesterol(b) Cholesterol(b) MES Cholesterol(b) Cholesterol synthesis from minimal exchange set and excretion into bile 18.421 O2(s) 3.11989 Glucose(s) 0.701651 Phenylalanine(s) 0.701651 Leucine(s) 1.15212 Palmitolate(s) 19.0176886792453 H2O(s) 19.9764150943396 CO2(s) 0.701650943396227 Urea(s) 0.99999999999997 Cholesterol(b) 42 43 18 6 - - - - 39 Bilirubin-way Bilirubin-bisglucuronoside(b) MES -Bilirubin(s) Bilirubin(s) test the import of blood Bilirubin and the bile excretion of conjugated Bilirubin 2.21327 O2(s) 2 Glucose(s) 1 Bilirubin(s) 0.00947867 Palmitolate(s) 4.14218009478674 H2O(s) 0.151658767772511 CO2(s) 0.99999999999997 Bilirubin-bisglucuronoside(b) 12 39 2 - - - - - 24 Other functions Mannose-1P(c) Mannose-1P(c) MES Mannose-1P(c) test that cytosolic Mannose-1P can be produced from the minimal exchange set 0.42654 O2(s) 1 Pi(s) 1 Glucose(s) 0.0189573 Palmitolate(s) 1.28436018957346 H2O(s) 0.303317535545024 CO2(s) 0.99999999999997 Mannose-1P(c) 11 39 - - - - - - 20 Mannose-6P(c) Mannose-6P(c) MES Mannose-6P(c) test that cytosolic Mannose-6P can be produced from the minimal exchange set 0.42654 O2(s) 1 Pi(s) 1 Glucose(s) 0.0189573 Palmitolate(s) 1.28436018957346 H2O(s) 0.303317535545024 CO2(s) 0.99999999999997 Mannose-6P(c) 10 39 - - - - - - 20 Fructose-6P(c) HC00088(c) MES HC00088(c) test that cytosolic Fructose-6P can be produced from the minimal exchange set 0.42654 O2(s) 1 Pi(s) 1 Glucose(s) 0.0189573 Palmitolate(s) 1.28436018957346 H2O(s) 0.303317535545024 CO2(s) 0.99999999999997 Fructose-6P(c) 9 39 - - - - - - 20 D-4-Phosphopantothenate(c) D-4-Phosphopantothenate(c) MES D-4-Phosphopantothenate(c) test that cytosolic D-4-Phosphopantothenate can be produced from the minimal exchange set 0.63981 O2(s) 1 Pi(s) 1 Pantothenate(s) 0.028436 Palmitolate(s) 1.42654028436019 H2O(s) 0.454976303317536 CO2(s) 0.99999999999997 D-4-Phosphopantothenate(c) 8 39 - - - - - - 20 PAPS(c) PAPS(c) MES PAPS(c) test that cytosolic PAPS can be produced from the minimal exchange set 5.5 O2(s) 2 Pi(s) 2 NH3(s) 1.33333 Glucose(s) 1 Sulfate(s) 1 Histidine(s) 12 H2O(s) 4 CO2(s) 0.99999999999997 PAPS(c) 55 12 - - - - - - 34 PAP_degradation -1 PAP(c) =H2O(s) +Pi(c) +AMP(c) PAP(c) test that cytosolic PAPcan be degraded to AMP and phosphate 1 H2O(s) 1 PAP(c) 1.00000000000003 Pi(c) 1.00000000000003 AMP(c) 1 - - - - - - - 1 Tetrahydrobiopterin(c) Tetrahydrobiopterin(c) MES Tetrahydrobiopterin(c) test that cytosolic Tetrahydrobiopterin can be produced from the minimal exchange set 3.60526 O2(s) 3.58647 NH3(s) 1.33333 Glucose(s) 0.413534 Histidine(s) 0.172932 Valine(s) 8.69172932330827 H2O(s) 2.34586466165413 CO2(s) 0.99999999999997 Tetrahydrobiopterin(c) 51 23 - - - - - - 28 Dihydrobiopterin(c) Dihydrobiopterin(c) MES Dihydrobiopterin(c) test that cytosolic Dihydrobiopterin can be produced from the minimal exchange set 3.78947 O2(s) 4.53509 NH3(s) 1.33333 Glucose(s) 0.464912 Valine(s) 10.859649122807 H2O(s) 1.32456140350878 CO2(s) 0.99999999999997 Dihydrobiopterin(c) 44 22 - - - - - - 25 5,10-Methylene-THF(c) 5,10-Methylene-THF(c) MES 5,10-Methylene-THF(c) test that cytosolic 5,10-Methylene-THF can be produced from the minimal exchange set 0.5 H2O(s) 3 O2(s) 1 Histidine(s) 1 Folate(s) 3.5 CO2(s) 1.5 Urea(s) 0.99999999999997 5,10-Methylene-THF(c) 29 14 - - - - - - 24 N-Acetylglucosamine-6P(c) N-Acetylglucosamine-6P(c) MES N-Acetylglucosamine-6P(c) test that cytosolic N-Acetylglucosamine-6P can be produced from the minimal exchange set 0.659574 O2(s) 1 Pi(s) 0.510638 NH3(s) 1 Glucose(s) 0.489362 Ethanolamine(c) 0.0638298 Palmitolate(s) 2.93617021276596 H2O(s) 0.99999999999997 N-Acetylglucosamine-6P(c) 14 30 - - - - - - 20 THF(c) THF(c) MES THF(c) test that cytosolic THF can be produced from the minimal exchange set 0.971429 H2O(s) 0.0285714 O2(s) 0.171429 Glucose(s) 1 Folate(s) 1.02857142857143 CO2(s) 0.99999999999997 THF(c) 26 8 - - - - - - 18 THF(m) THF(m) MES THF(m) test that mitochondrial THF can be produced from the minimal exchange set 1 H2O(s) 0.333333 O2(s) 0.222222 Valine(s) 1 Folate(s) 1 CO2(s) 0.111111111111111 Urea(s) 0.99999999999997 THF(m) 8 28 - - - - - - 23 10-Formyl-THF(c) 10-Formyl-THF(c) MES 10-Formyl-THF(c) test that cytosolic 10-Formyl-THF can be produced from the minimal exchange set 0.5 H2O(s) 3.5 O2(s) 1 Histidine(s) 1 Folate(s) 3.5 CO2(s) 1.5 Urea(s) 0.99999999999997 10-Formyl-THF(c) 30 13 - - - - - - 25 Acetoacetate(s) Acetoacetate(s) MES Acetoacetate(s) test that Acetoacetate can be produced and excreted into the blood from the minimal exchange set 2.09375 O2(s) 0.4375 Phenylalanine(s) 0.229167 Leucine(s) 0.229166666666667 H2O(s) 0.979166666666666 CO2(s) 0.333333333333333 Urea(s) 0.99999999999997 Acetoacetate(s) 27 17 - - - - - - 26 Acetone(s) Acetone(s) MES Acetone(s) test that Acetone can be produced and excreted into the blood from the minimal exchange set 1.83333 O2(s) 0.333333 Phenylalanine(s) 0.333333 Leucine(s) 0.333333333333334 H2O(s) 1.66666666666667 CO2(s) 0.333333333333333 Urea(s) 0.99999999999997 Acetone(s) 24 16 - - - - - - 22 Chitin_degradation -1 Chitin-component(s) DES Chitin-component(s) test that Chitin can be degraded using the digestion target set 1.90361 H2O(s) 0.644578 O2(s) 1 Chitin-component(s) 1.03614457831325 CO2(s) 1 NH3(s) 1 Glucose(s) 0.0602409638554217 Palmitolate(s) 51 13 1 - 1 - 1 - 28 FAD(s) FAD(s) MES FAD(s) test that FAD can be produced and excreted into the blood from the minimal exchange set 5.5 O2(s) 2 Pi(s) 2 NH3(s) 1.33333 Glucose(s) 1 Histidine(s) 1 Riboflavin(s) 12 H2O(s) 4 CO2(s) 0.99999999999997 FAD(s) 56 12 - - - - - - 33 Pyridoxal-P(c) Pyridoxal-P(c) MES Pyridoxal-P(c) test that cytosolic Pyridoxal-P can be produced from the minimal exchange set 0.92654 O2(s) 1 Pi(s) 1 Pyridoxine(s) 0.0189573 Palmitolate(s) 2.28436018957346 H2O(s) 0.303317535545024 CO2(s) 0.99999999999997 Pyridoxal-P(c) 10 39 - - - - - - 20 S-Adenosylmethioninamine(c) S-Adenosylmethioninamine(c) MES S-Adenosylmethioninamine(c) test that cytosolic S-Adenosylmethioninamine can be produced from the minimal exchange set 5.5 O2(s) 2 NH3(s) 1.33333 Glucose(s) 1 Methionine(s) 1 Histidine(s) 10 H2O(s) 5 CO2(s) 0.99999999999997 S-Adenosylmethioninamine(c) 55 11 - - - - - - 28 Putrescine(c) Putrescine(c) MES Putrescine(c) test that cytosolic Putrescine can be produced from the minimal exchange set 0.5 O2(s) 1 NH3(s) 1 Valine(s) 1 H2O(s) 1 CO2(s) 0.99999999999997 Putrescine(c) 1 13 - - - - - - 14 Spermidine Spermidine(s) MES +Methylthioribose-1P(c) Spermidine(s) test that cytosolic Spermidine can be produced from the minimal exchange set while the cytosolic dump of Methylthioribose-1P is allowed 1.68966 O2(s) 1 Pi(s) 0.801724 NH3(s) 0.833333 Glucose(s) 1 Methionine(s) 1.19828 Valine(s) 3.79310344827586 H2O(s) 2.99137931034483 CO2(s) 0.99999999999997 Spermidine(s) 0.99999999999982 Methylthioribose-1P(c) 20 23 - - - - - - 26 Spermine Spermine(s) MES +Methylthioribose-1P(c) Spermine(s) test that cytosolic Spermine can be produced from the minimal exchange set while the cytosolic dump of Methylthioribose-1P is allowed 2.93103 O2(s) 2 Pi(s) 0.594828 NH3(s) 1.66667 Glucose(s) 2 Methionine(s) 1.40517 Valine(s) 6.62068965517242 H2O(s) 5.02586206896552 CO2(s) 0.99999999999997 Spermine(s) 1.99999999999913 Methylthioribose-1P(c) 21 23 - - - - - - 26 Methylthioribose-1P(c) Methylthioribose-1P(c) +Spermidine(s) MES Methylthioribose-1P(c) test that cytosolic Methylthioribose-1P can be produced from the minimal exchange set while the cytosolic dump of Spermidine is allowed 1.68966 O2(s) 1 Pi(s) 0.801724 NH3(s) 0.833333 Glucose(s) 1 Methionine(s) 1.19828 Valine(s) 3.79310344827586 H2O(s) 2.99137931034483 CO2(s) 0.99999999999973 Spermidine(s) 0.99999999999997 Methylthioribose-1P(c) 20 23 - - - - - - 26 Ammonia_to_urea -1 NH3(s) -O2(s) -Glucose(s) +CO2(s) =H2O(s) +Urea(s) NH3(s) test the conversion of imported ammonium to excreted urea while the oxidation of glucose to CO2 is allowed 0.5 O2(s) 1 NH3(s) 0.0833333 Glucose(s) 1 H2O(s) 0.5 Urea(s) 20 15 - - - - - - 24 Ammonia_to_gln -1 NH3(s) -Glutamate(s) +Glutamine(s) =H2O(s) -Glucose(s) +CO2(s) -O2(s) NH3(s) test the conversion of imported ammonium to excreted glutamine while the uptake of glutamate is allowed 0.25 O2(s) 1 NH3(s) 0.666667 Glutamate(s) 0.166667 Glucose(s) 1.33333333333333 H2O(s) 0.166666666666667 CO2(s) 0.833333333333333 Glutamine(s) 14 8 - - - - 4 - 28 Ammonia_to_glu -1 NH3(s) +Glutamate(s) =H2O(s) -Glucose(s) +CO2(s) -O2(s) NH3(s) test the conversion of imported ammonium to excreted glutamate is allowed 0.973684 O2(s) 1 NH3(s) 0.912281 Glucose(s) 2.47368421052632 H2O(s) 0.473684210526316 CO2(s) 1 Glutamate(s) 42 11 - - - - 2 - 21 Ammonia_to_ala -1 NH3(s) +Alanine(s) =H2O(s) -Glucose(s) +CO2(s) -O2(s) NH3(s) test the conversion of imported ammonium to excreted alanine is allowed 0.165138 O2(s) 1 NH3(s) 0.527523 Glucose(s) 1.1651376146789 H2O(s) 0.165137614678899 CO2(s) 1 Alanine(s) 19 18 - - - - - - 24 Ammonia_adlib -1 NH3(s) -O2(s) -Alanine(s) =Glucose(s) -Glutamate(s) -Aspartate(s) -Malate(c) -AKG(s) +CO2(s) +Urea(s) +Glutamine(s) +ATP-energy(c) +NADH-redox-potential(c) +NADPH-redox-potential(c) NH3(s) test that ammonium can be converted while uptake of alanine glucose glutamate oxygene and the excretion of urea glutamine CO2 glucose is allowed 0.105769 O2(s) 1 NH3(s) 0.403846 AKG(s) 0.282051 Glucose(s) 1.21153846153846 CO2(s) 0.5 Glutamine(s) 0.346153846153846 NADH-redox-potential(c) 1.55769230769231 NADPH-redox-potential(c) 24 10 - - - - - - 24 NAD(c) NAD+(c) MES NAD+(c) test that cytosolic NAD+ can be produced from the minimal exchange set 5.89535 O2(s) 2 Pi(s) 3.18605 NH3(s) 2.16667 Glucose(s) 0.395349 Tryptophan(s) 0.604651 Histidine(s) 0.604651 Nicotinamide(s) 14.1860465116279 H2O(s) 0.99999999999997 NAD+(c) 3.6046511627907 CO2(s) 58 15 - - - - - - 31 NADP(c) NADP+(c) MES NADP+(c) test that cytosolic NADP+ can be produced from the minimal exchange set 5.7093 O2(s) 3 Pi(s) 2.62791 NH3(s) 2.16667 Glucose(s) 0.209302 Tryptophan(s) 0.790698 Histidine(s) 0.790698 Nicotinamide(s) 14.6279069767442 H2O(s) 0.99999999999997 NADP+(c) 3.79069767441861 CO2(s) 59 14 - - - - - - 31 Biotransformation and catabolic functions O2(s)_waste -1 O2(s) DES O2(s) test that O2 can be degraded using the digestion target set 1 O2(s) 0.1 Phenylalanine(s) 0.4 H2O(s) 0.9 CO2(s) 0.1 NH3(s) 2.96666666666667 ATP-energy(m) 20 16 - - - - - - 21 CO2(s)_waste -1 CO2(s) DES CO2(s) test that CO2 can be degraded using the digestion target set 2.66667 O2(s) 1 CO2(s) 4.96296 NH3(s) 0.592593 Isoleucine(s) 3.96296296296296 H2O(s) 0.296296296296296 Glucose(s) 2.77777777777778 Urea(s) 20 25 1 - - - - - 29 PPi(c)_waste -1 PPi(c) DES PPi(c) test that PPi can be degraded using the digestion target set 1 H2O(s) 1 PPi(c) 2 Pi(s) 1 - - - - - - - 2 NH3(s)_waste -1 NH3(s) DES NH3(s) test that NH3 can be degraded using the digestion target set 0.41129 O2(s) 0.0887097 CO2(s) 1 NH3(s) 0.0685484 Glucose(s) 0.911290322580645 H2O(s) 0.5 Urea(s) 18 16 - - - - - - 23 FAD(s)_waste -1 FAD(s) DES FAD(s) test that FAD can be degraded using the digestion target set 5 H2O(s) 1 O2(s) 1 FAD(s) 2 Pi(s) 1 NH3(s) 0.833333333333333 Glucose(s) 0.99999999999997 Riboflavin(s) 1 Urate(s) 21 - 1 - - - - - 11 Pyruvate(s)_waste -1 Pyruvate(s) DES Pyruvate(s) test that Pyruvate can be degraded using the digestion target set 0.0361672 H2O(s) 0.329967 O2(s) 1 Pyruvate(s) 0.945984030061061 CO2(s) 0.294739314232034 Glucose(s) 0.017848755284171 Palmitolate(s) 54 16 1 - - - - - 27 Glutamate(s)_waste -1 Glutamate(s) DES Glutamate(s) test that Glutamate can be degraded using the digestion target set 1.5 O2(s) 1 Glutamate(s) 2 CO2(s) 1 NH3(s) 0.5 Glucose(s) 4.33333333333333 ATP-energy(m) 10 8 1 - - - - - 24 AKG(s)_waste -1 AKG(s) DES AKG(s) test that AKG can be degraded using the digestion target set 1 O2(s) 1 AKG(s) 2 CO2(s) 0.5 Glucose(s) 3.66666666666667 ATP-energy(m) 10 5 1 - - - - - 21 Glucose(s)_waste -1 Glucose(s) DES Glucose(s) test that Glucose can be degraded using the digestion target set 0.43299 O2(s) 1 Glucose(s) 2.28865979381443 H2O(s) 2.04123711340206 CO2(s) 0.247422680412371 Palmitolate(s) 66 11 - - - - - - 17 Acetate(s)_waste -1 Acetate(s) DES Acetate(s) test that Acetate can be degraded using the digestion target set 0.489649 O2(s) 1 Acetate(s) 0.993099121706399 H2O(s) 0.925972396486826 CO2(s) 0.0671267252195734 Palmitolate(s) 48 15 - - - - - - 22 GDP(s)_waste -1 GDP(s) DES GDP(s) test that GDP can be degraded using the digestion target set 3.81818 H2O(s) 0.681818 O2(s) 1 GDP(s) 1.99999999999991 Pi(s) 0.181818181818182 CO2(s) 1 NH3(s) 0.803030303030303 Glucose(s) 1 Urate(s) 21 11 1 - - - 2 - 21 Glycine(s)_waste -1 Glycine(s) DES Glycine(s) test that Glycine can be degraded using the digestion target set 4.64706 H2O(s) 0.852941 O2(s) 1 Glycine(s) 1 Histidine(s) 2.35294117647059 CO2(s) 4 NH3(s) 0.941176470588235 Glucose(s) 22 10 1 - - - - - 26 Alanine(s)_waste -1 Alanine(s) DES Alanine(s) test that Alanine can be degraded using the digestion target set 0.596542 H2O(s) 0.302594 O2(s) 1 Alanine(s) 0.390009606147935 CO2(s) 1 NH3(s) 0.399135446685879 Glucose(s) 0.0134486071085495 Palmitolate(s) 55 18 1 - - - - - 27 Succinate(s)_waste -1 Succinate(s) DES Succinate(s) test that Succinate can be degraded using the digestion target set 1.10323 O2(s) 1 Succinate(s) 0.791741472172353 H2O(s) 1.76660682226212 CO2(s) 0.305206463195691 Glucose(s) 0.0251346499102334 Palmitolate(s) 54 10 1 - - - - - 28 UDP-N-acetylglucosamine(c)_waste -1 UDP-N-acetylglucosamine(c) DES UDP-N-acetylglucosamine(c) test that UDP-N-acetylglucosamine can be degraded using the digestion target set 7.15354 H2O(s) 1.01378 O2(s) 1 UDP-N-acetylglucosamine(c) 2 Pi(s) 3.61417322834646 CO2(s) 3 NH3(s) 1.79068241469816 Glucose(s) 0.0511811023622047 Cholesterol(b) 0.078740157480315 Palmitolate(s) 71 17 19 6 - - - - 40 GTP(s)_waste -1 GTP(s) DES GTP(s) test that GTP can be degraded using the digestion target set 4.81818 H2O(s) 0.681818 O2(s) 1 GTP(s) 2.99999999999982 Pi(s) 0.181818181818182 CO2(s) 1 NH3(s) 0.803030303030303 Glucose(s) 1 Urate(s) 21 11 1 - - - 3 - 21 Aspartate(s)_waste -1 Aspartate(s) DES Aspartate(s) test that Aspartate can be degraded using the digestion target set 0.327731 H2O(s) 0.504202 O2(s) 1 Aspartate(s) 1.64985994397759 CO2(s) 1 NH3(s) 0.331932773109244 Glucose(s) 0.0224089635854342 Palmitolate(s) 58 16 1 - - - - - 33 GSH(s)_waste -1 GSH(s) DES GSH(s) test that GSH can be degraded using the digestion target set 4.6037 H2O(s) 10.8429 O2(s) 1 GSH(s) 1.91191 Tryptophan(s) 12.3725584067407 CO2(s) 2.91191114515511 NH3(s) 1.25639920847696 Glucose(s) 1 Methionine(s) 1.45595557257756 Urea(s) 0.088088854844887 Cholesterol(b) 0.142857142857143 Palmitolate(s) 86 26 20 6 - - 2 - 50 CMP(s)_waste -1 CMP(s) DES CMP(s) test that CMP can be degraded using the digestion target set 5.30284 H2O(s) 0.444895 O2(s) 1 CMP(s) 0.99999999999994 Pi(s) 2.57534246575343 CO2(s) 3 NH3(s) 0.816526784467646 Glucose(s) 0.0201678586388247 Cholesterol(b) 0.061310290262027 Palmitolate(s) 69 18 19 6 - - 1 - 41 Formate(c)_waste -1 Formate(c) DES Formate(c) test that Formate can be degraded using the digestion target set 0.5 O2(s) 1 Formate(c) 0.999999999999999 H2O(s) 1 CO2(s) 13 - - - - - - - 11 Arginine(s)_waste -1 Arginine(s) DES Arginine(s) test that Arginine can be degraded using the digestion target set 1 H2O(s) 2.5 O2(s) 1 Arginine(s) 2 CO2(s) 2 NH3(s) 0.5 Glucose(s) 1 Urea(s) 11 ATP-energy(m) 11 10 1 - - - - - 24 CTP(s)_waste -1 CTP(s) DES CTP(s) test that CTP can be degraded using the digestion target set 7.30284 H2O(s) 0.444895 O2(s) 1 CTP(s) 2.99999999999982 Pi(s) 2.57534246575343 CO2(s) 3 NH3(s) 0.816526784467646 Glucose(s) 0.0201678586388247 Cholesterol(b) 0.061310290262027 Palmitolate(s) 69 18 19 6 - - 3 - 41 Glutamine(s)_waste -1 Glutamine(s) DES Glutamine(s) test that Glutamine can be degraded using the digestion target set 1 H2O(s) 1.5 O2(s) 1 Glutamine(s) 2 CO2(s) 2 NH3(s) 0.5 Glucose(s) 5.66666666666667 ATP-energy(m) 10 9 1 - - - - - 22 Serine(s)_waste -1 Serine(s) DES Serine(s) test that Serine can be degraded using the digestion target set 0.0361672 H2O(s) 0.329967 O2(s) 1 Serine(s) 0.945984030061062 CO2(s) 1 NH3(s) 0.294739314232034 Glucose(s) 0.0178487552841709 Palmitolate(s) 56 15 1 - - - - - 26 PEP(c)_waste -1 PEP(c) DES PEP(c) test that PEP can be degraded using the digestion target set 1.33824 H2O(s) 0.161765 O2(s) 1 PEP(c) 1 Pi(s) 0.661764705882353 CO2(s) 0.389705882352941 Glucose(s) 17 8 1 - - - - - 21 UTP(s)_waste -1 UTP(s) DES UTP(s) test that UTP can be degraded using the digestion target set 5.83013 H2O(s) 0.582244 O2(s) 1 UTP(s) 3 Pi(s) 2.57647963105304 CO2(s) 1.80784012298232 NH3(s) 0.769280040994107 Glucose(s) 0.0480399692544197 Cholesterol(b) 0.0480399692544197 Urate(s) 0.0169100691775557 Palmitolate(s) 0.947476300281834 ATP-energy(c) 97 11 19 6 - - - - 45 Ornithine(s)_waste -1 Ornithine(s) DES Ornithine(s) test that Ornithine can be degraded using the digestion target set 2.5 O2(s) 1 Ornithine(s) 2 CO2(s) 2 NH3(s) 0.5 Glucose(s) 11 ATP-energy(m) 10 10 1 - - - - - 22 Tryptophan(s)_waste -1 Tryptophan(s) DES Tryptophan(s) test that Tryptophan can be degraded using the digestion target set 2.82282 H2O(s) 4.26577 O2(s) 1 Tryptophan(s) 4.98898898898899 CO2(s) 2 NH3(s) 0.5 Glucose(s) 0.188188188188188 Palmitolate(s) 66 20 1 - - - - - 30 Phenylalanine(s)_waste -1 Phenylalanine(s) DES Phenylalanine(s) test that Phenylalanine can be degraded using the digestion target set 0.822739 H2O(s) 4.18839 O2(s) 1 Phenylalanine(s) 4.0288768048003 CO2(s) 1 NH3(s) 0.487082525991208 Glucose(s) 0.0155009688105507 Cholesterol(b) 0.101881367585474 Palmitolate(s) 71 16 19 6 - - - - 45 Tyrosine(s)_waste -1 Tyrosine(s) DES Tyrosine(s) test that Tyrosine can be degraded using the digestion target set 1.2557 H2O(s) 3.09426 O2(s) 1 Tyrosine(s) 3.58622413900869 CO2(s) 1 NH3(s) 0.496301852199096 Glucose(s) 0.00443777736108506 Cholesterol(b) 0.144759047440465 Palmitolate(s) 71 16 19 6 - - - - 44 Acetaldehyde(s)_waste -1 Acetaldehyde(s) DES Acetaldehyde(s) test that Acetaldehyde can be degraded using the digestion target set 0.466867 O2(s) 1 Acetaldehyde(s) 0.644578313253012 H2O(s) 0.554216867469879 CO2(s) 0.0903614457831325 Palmitolate(s) 44 15 - - - - - - 20 Sucrose(s)_waste -1 Sucrose(s) DES Sucrose(s) test that Sucrose can be degraded using the digestion target set 0.8125 H2O(s) 0.1875 O2(s) 1 Sucrose(s) 0.1875 CO2(s) 1.96874999999997 Glucose(s) 12 11 1 - - - 1 - 19 Glucose-6P(c)_waste -1 Glucose-6P(c) DES Glucose-6P(c) test that Glucose-6P can be degraded using the digestion target set 1 H2O(s) 1 Glucose-6P(c) 1 Pi(s) 1 Glucose(s) - - 1 - - - - - 6 sn-Glycerol-3P(c)_waste -1 sn-Glycerol-3P(c) DES sn-Glycerol-3P(c) test that sn-Glycerol-3P can be degraded using the digestion target set 0.5 O2(s) 1 sn-Glycerol-3P(c) 1 Pi(s) 0.5 Glucose(s) 2 ATP-energy(m) 4 1 1 - - - - - 12 Sulfite(c)_waste -1 Sulfite(c) DES Sulfite(c) test that Sulfite can be degraded using the digestion target set 0.716216 O2(s) 1 Sulfite(c) 0.036036 Valine(s) 0.144144144144144 H2O(s) 0.18018018018018 CO2(s) 0.036036036036036 NH3(s) 1 Sulfate(s) - 25 - - - - 2 - 17 Fructose(s)_waste -1 Fructose(s) DES Fructose(s) test that Fructose can be degraded using the digestion target set 0.1875 O2(s) 1 Fructose(s) 0.1875 H2O(s) 0.1875 CO2(s) 0.96875 Glucose(s) 11 12 1 - - - - - 18 Cysteine(s)_waste -1 Cysteine(s) DES Cysteine(s) test that Cysteine can be degraded using the digestion target set 1.77949 H2O(s) 4.67761 O2(s) 0.975871 Tryptophan(s) 1 Cysteine(s) 4.97922252010724 CO2(s) 0.975871313672922 NH3(s) 0.435991957104559 Glucose(s) 1 Methionine(s) 0.487935656836461 Urea(s) 0.0241286863270777 Cholesterol(b) 49 24 19 6 - - - - 45 beta-Alanine(s)_waste -1 beta-Alanine(s) DES beta-Alanine(s) test that beta-Alanine can be degraded using the digestion target set 0.261236 O2(s) 1 beta-Alanine(s) 0.174157303370787 H2O(s) 1.05243445692884 CO2(s) 1 NH3(s) 0.121722846441948 Palmitolate(s) 54 19 - - - - - - 25 Uracil(s)_waste -1 Uracil(s) DES Uracil(s) test that Uracil can be degraded using the digestion target set 2.35452 H2O(s) 0.400722 O2(s) 0.0112502 Glucose(s) 1 Uracil(s) 2.53178023550317 CO2(s) 2 NH3(s) 0.0135001817332156 Cholesterol(b) 0.0732009853978794 Palmitolate(s) 67 20 19 6 - - - - 44 CDP(s)_waste -1 CDP(s) DES CDP(s) test that CDP can be degraded using the digestion target set 6.30284 H2O(s) 0.444895 O2(s) 1 CDP(s) 1.99999999999982 Pi(s) 2.57534246575343 CO2(s) 3 NH3(s) 0.816526784467646 Glucose(s) 0.0201678586388247 Cholesterol(b) 0.061310290262027 Palmitolate(s) 69 18 19 6 - - 2 - 41 Glycerol(s)_waste -1 Glycerol(s) DES Glycerol(s) test that Glycerol can be degraded using the digestion target set 0.5 O2(s) 1 Glycerol(s) 0.999999999999998 H2O(s) 0.5 Glucose(s) 0.666666666666669 ATP-energy(m) 5 1 1 - - - - - 15 Ribose(s)_waste -1 Ribose(s) DES Ribose(s) test that Ribose can be degraded using the digestion target set 0.181818 O2(s) 1 Ribose(s) 0.181818181818182 H2O(s) 0.181818181818182 CO2(s) 0.803030303030303 Glucose(s) 16 12 1 - - - - - 18 Galactose(s)_waste -1 Galactose(s) DES Galactose(s) test that Galactose can be degraded using the digestion target set 0.1875 O2(s) 1 Galactose(s) 0.1875 H2O(s) 0.1875 CO2(s) 0.96875 Glucose(s) 14 12 1 - - - - - 18 Inositol(s)_waste -1 Inositol(s) DES Inositol(s) test that Inositol can be degraded using the digestion target set 1.3125 O2(s) 1 Inositol(s) 1.31250000000012 H2O(s) 1.31250000000003 CO2(s) 0.781249999999994 Glucose(s) 36 11 1 - - - - - 19 GMP(s)_waste -1 GMP(s) DES GMP(s) test that GMP can be degraded using the digestion target set 2.81818 H2O(s) 0.681818 O2(s) 1 GMP(s) 0.99999999999997 Pi(s) 0.181818181818182 CO2(s) 1 NH3(s) 0.803030303030303 Glucose(s) 1 Urate(s) 21 11 1 - - - 1 - 21 Adenine(s)_waste -1 Adenine(s) DES Adenine(s) test that Adenine can be degraded using the digestion target set 0.783784 H2O(s) 1.32432 O2(s) 1 Adenine(s) 0.0540541 Valine(s) 0.27027027027027 CO2(s) 1.05405405405405 NH3(s) 1 Urate(s) 12 23 - - - - - - 19 Proline(s)_waste -1 Proline(s) DES Proline(s) test that Proline can be degraded using the digestion target set 2 H2O(s) 1.5 O2(s) 1 Proline(s) 2 CO2(s) 1 NH3(s) 0.5 Glucose(s) 7 ATP-energy(m) 10 11 1 - - - - - 21 Malate(c)_waste -1 Malate(c) DES Malate(c) test that Malate can be degraded using the digestion target set 0.339823 O2(s) 1 Malate(c) 0.552212389380531 H2O(s) 1.52389380530973 CO2(s) 0.33716814159292 Glucose(s) 0.0283185840707965 Palmitolate(s) 55 16 1 - - - - - 23 Asparagine(s)_waste -1 Asparagine(s) DES Asparagine(s) test that Asparagine can be degraded using the digestion target set 1.54502 H2O(s) 0.341232 O2(s) 1 Asparagine(s) 1.43981042654028 CO2(s) 2 NH3(s) 0.386255924170616 Glucose(s) 0.0151658767772512 Palmitolate(s) 63 17 1 - - - - - 28 Citrate(s)_waste -1 Citrate(s) DES Citrate(s) test that Citrate can be degraded using the digestion target set 0.587591 O2(s) 1 Citrate(s) 0.40389294403893 H2O(s) 2.36171938361719 CO2(s) 0.493917274939173 Glucose(s) 0.0421735604217356 Palmitolate(s) 52 15 1 - - - - - 26 Mannose(s)_waste -1 Mannose(s) DES Mannose(s) test that Mannose can be degraded using the digestion target set 0.1875 O2(s) 1 Mannose(s) 0.1875 H2O(s) 0.1875 CO2(s) 0.96875 Glucose(s) 13 11 1 - - - - - 19 Propanoate(s)_waste -1 Propanoate(s) DES Propanoate(s) test that Propanoate can be degraded using the digestion target set 0.827103 O2(s) 1 Propanoate(s) 0.381619937694698 H2O(s) 0.374350986500518 CO2(s) 0.418224299065421 Glucose(s) 0.00726895119418486 Palmitolate(s) 57 22 1 - - - - - 29 Acetoacetate(s)_waste -1 Acetoacetate(s) DES Acetoacetate(s) test that Acetoacetate can be degraded using the digestion target set 0.772152 O2(s) 1 Acetoacetate(s) 0.848101265822784 H2O(s) 1.70464135021097 CO2(s) 0.143459915611814 Palmitolate(s) 49 16 - - - - - - 22 Valine(s)_waste -1 Valine(s) DES Valine(s) test that Valine can be degraded using the digestion target set 3 O2(s) 1 Valine(s) 1 H2O(s) 2 CO2(s) 1 NH3(s) 0.5 Glucose(s) 14.3333333333333 ATP-energy(m) 10 15 1 - - - - - 22 L-Lactate(s)_waste -1 L-Lactate(s) DES L-Lactate(s) test that L-Lactate can be degraded using the digestion target set 0.319868 O2(s) 1 L-Lactate(s) 0.85533114138093 H2O(s) 0.783936120244247 CO2(s) 0.178957256928135 Glucose(s) 0.0713950211366839 Palmitolate(s) 57 14 1 - - - - - 27 Ethanolamine(c)_waste -1 Ethanolamine(c) DES Ethanolamine(c) test that Ethanolamine can be degraded using the digestion target set 0.652632 O2(s) 1 Ethanolamine(c) 0.768421052631578 H2O(s) 0.686315789473684 CO2(s) 1 NH3(s) 0.0821052631578948 Palmitolate(s) 45 17 - - - - - - 18 UDP-N-acetyl-D-galactosamine(c)_waste -1 UDP-N-acetyl-D-galactosamine(c) DES UDP-N-acetyl-D-galactosamine(c) test that UDP-N-acetyl-D-galactosamine can be degraded using the digestion target set 7.15354 H2O(s) 1.01378 O2(s) 1 UDP-N-acetyl-D-galactosamine(c) 2 Pi(s) 3.61417322834646 CO2(s) 3 NH3(s) 1.79068241469816 Glucose(s) 0.0511811023622047 Cholesterol(b) 0.078740157480315 Palmitolate(s) 72 17 19 6 - - - - 40 Maltose(s)_waste -1 Maltose(s) DES Maltose(s) test that Maltose can be degraded using the digestion target set 1 H2O(s) 1 Maltose(s) 1.99999999999994 Glucose(s) - - - - - - 1 - - Adenosine(s)_waste -1 Adenosine(s) DES Adenosine(s) test that Adenosine can be degraded using the digestion target set 1.90909 H2O(s) 1.09091 O2(s) 1 Adenosine(s) 0.0909090909090909 CO2(s) 1 NH3(s) 0.818181818181818 Glucose(s) 1 Urate(s) 24 12 1 - - - - - 21 Guanine(s)_waste -1 Guanine(s) DES Guanine(s) test that Guanine can be degraded using the digestion target set 0.855856 H2O(s) 0.716216 O2(s) 0.036036 Valine(s) 1 Guanine(s) 0.18018018018018 CO2(s) 1.03603603603604 NH3(s) 1 Urate(s) 3 23 - - - - - - 18 Lactose(s)_waste -1 Lactose(s) DES Lactose(s) test that Lactose can be degraded using the digestion target set 0.8125 H2O(s) 0.1875 O2(s) 1 Lactose(s) 0.1875 CO2(s) 1.96874999999994 Glucose(s) 14 12 1 - - - 1 - 18 Taurine(s)_waste -1 Taurine(s) DES Taurine(s) test that Taurine can be degraded using the digestion target set 2.2705 H2O(s) 3.49011 O2(s) 1 Tryptophan(s) 1 Taurine(s) 4.56798516687268 CO2(s) 1.86114544705398 NH3(s) 0.5 Glucose(s) 1 Methionine(s) 0.0694272764730122 Urea(s) 0.0226617222908941 Palmitolate(s) 83 26 1 - - - - - 35 Palmitate(s)_waste -1 Palmitate(s) DES Palmitate(s) test that Palmitate can be degraded using the digestion target set 1.19231 O2(s) 0.115385 Glucose(s) 1 Palmitate(s) 1.69230769230769 H2O(s) 0.692307692307692 CO2(s) 1 Palmitolate(s) 25 10 - - - - - - 20 Isomaltose(s)_waste -1 Isomaltose(s) DES Isomaltose(s) test that Isomaltose can be degraded using the digestion target set 1 H2O(s) 1 Isomaltose(s) 1.99999999999994 Glucose(s) - - - - - - 1 - - H2S(s)_waste -1 H2S(s) DES H2S(s) test that H2S can be degraded using the digestion target set 0.519446 H2O(s) 4.32634 O2(s) 0.0378213 Glucose(s) 0.971634 Tryptophan(s) 1 H2S(s) 4.46502428634217 CO2(s) 0.261199328322045 NH3(s) 1 Methionine(s) 0.341034338971972 Urea(s) 0.0283659968670055 Cholesterol(b) 0.0214350917922306 Palmitolate(s) 88 26 19 6 - - - - 47 Inosine(s)_waste -1 Inosine(s) DES Inosine(s) test that Inosine can be degraded using the digestion target set 0.727273 H2O(s) 1.27273 O2(s) 1 Inosine(s) 0.272727272727272 CO2(s) 0.787878787878788 Glucose(s) 1 Urate(s) 27 12 1 - - - - - 20 Orotate(s)_waste -1 Orotate(s) DES Orotate(s) test that Orotate can be degraded using the digestion target set 2.37056 H2O(s) 0.444162 O2(s) 1 Orotate(s) 3.53807106598985 CO2(s) 2 NH3(s) 0.0913705583756345 Palmitolate(s) 58 18 - - - - - - 24 Uridine(s)_waste -1 Uridine(s) DES Uridine(s) test that Uridine can be degraded using the digestion target set 3.30284 H2O(s) 0.444895 O2(s) 1 Uridine(s) 2.57534246575342 CO2(s) 2 NH3(s) 0.816526784467646 Glucose(s) 0.0201678586388247 Cholesterol(b) 0.0613102902620269 Palmitolate(s) 67 19 19 6 - - - - 41 Citrulline(s)_waste -1 Citrulline(s) DES Citrulline(s) test that Citrulline can be degraded using the digestion target set 2.5 O2(s) 1 Citrulline(s) 2 CO2(s) 1 NH3(s) 0.5 Glucose(s) 1 Urea(s) 8.66666666666667 ATP-energy(m) 16 12 1 - - - - - 25 Glucosamine(s)_waste -1 Glucosamine(s) DES Glucosamine(s) test that Glucosamine can be degraded using the digestion target set 0.8125 H2O(s) 0.1875 O2(s) 1 Glucosamine(s) 0.1875 CO2(s) 1 NH3(s) 0.96875 Glucose(s) 12 12 1 - - - - - 19 Deoxyguanosine(s)_waste -1 Deoxyguanosine(s) DES Deoxyguanosine(s) test that Deoxyguanosine can be degraded using the digestion target set 1.25806 H2O(s) 1.1129 O2(s) 1 Deoxyguanosine(s) 0.658064516129032 CO2(s) 1 NH3(s) 0.5 Glucose(s) 1 Urate(s) 0.0838709677419355 Palmitolate(s) 54 16 1 - - - - - 25 Guanosine(s)_waste -1 Guanosine(s) DES Guanosine(s) test that Guanosine can be degraded using the digestion target set 1.81818 H2O(s) 0.681818 O2(s) 1 Guanosine(s) 0.181818181818182 CO2(s) 1 NH3(s) 0.803030303030303 Glucose(s) 1 Urate(s) 21 11 1 - - - - - 21 Histidine(s)_waste -1 Histidine(s) DES Histidine(s) test that Histidine can be degraded using the digestion target set 3 H2O(s) 2 O2(s) 1 Histidine(s) 3 CO2(s) 3 NH3(s) 0.5 Glucose(s) 5 ATP-energy(m) 25 8 1 - - - - - 23 Ethanol(s)_waste -1 Ethanol(s) DES Ethanol(s) test that Ethanol can be degraded using the digestion target set 0.560241 O2(s) 1 Ethanol(s) 1.37349397590361 H2O(s) 0.265060240963855 CO2(s) 0.108433734939759 Palmitolate(s) 44 17 - - - - - - 18 Cytidine(s)_waste -1 Cytidine(s) DES Cytidine(s) test that Cytidine can be degraded using the digestion target set 4.30284 H2O(s) 0.444895 O2(s) 1 Cytidine(s) 2.57534246575342 CO2(s) 3 NH3(s) 0.816526784467646 Glucose(s) 0.0201678586388247 Cholesterol(b) 0.061310290262027 Palmitolate(s) 69 18 19 6 - - - - 41 Cystine(s)_waste -1 Cystine(s) DES Cystine(s) test that Cystine can be degraded using the digestion target set 3.43438 H2O(s) 9.27977 O2(s) 1.95513 Tryptophan(s) 1 Cystine(s) 11.5644028103044 CO2(s) 2.54548009367682 NH3(s) 0.293731459797033 Glucose(s) 2 Methionine(s) 0.6823887587822 Urea(s) 0.044871194379391 Cholesterol(b) 0.142857142857143 Palmitolate(s) 91 25 19 6 - - 4 - 52 Methionine(s)_waste -1 Methionine(s) DES +Taurine(c) Methionine(s) test that Methionine can be degraded using the digestion target set 4.6875 O2(s) 0.5 Glucose(s) 1 Methionine(s) 3.125 H2O(s) 4 CO2(s) 1 Taurine(c) 0.125 Palmitolate(s) 7.64583333333333 ATP-energy(m) 70 16 - - - - - - 25 Deoxyuridine(s)_waste -1 Deoxyuridine(s) DES Deoxyuridine(s) test that Deoxyuridine can be degraded using the digestion target set 2.58887 H2O(s) 0.977981 O2(s) 1 Deoxyuridine(s) 3.19044988645431 CO2(s) 2 NH3(s) 0.476881687432231 Glucose(s) 0.0277419750813233 Cholesterol(b) 0.137451666359786 Palmitolate(s) 65 16 20 6 - - - - 42 Methylglyoxal(s)_waste -1 Methylglyoxal(s) DES Methylglyoxal(s) test that Methylglyoxal can be degraded using the digestion target set 0.144669 H2O(s) 0.319868 O2(s) 1 Methylglyoxal(s) 0.783936120244246 CO2(s) 0.178957256928135 Glucose(s) 0.0713950211366839 Palmitolate(s) 56 15 1 - - - - - 25 Deoxyadenosine(s)_waste -1 Deoxyadenosine(s) DES Deoxyadenosine(s) test that Deoxyadenosine can be degraded using the digestion target set 1.26506 H2O(s) 1.60241 O2(s) 1 Deoxyadenosine(s) 0.650602409638554 CO2(s) 1 NH3(s) 0.5 Glucose(s) 1 Urate(s) 0.0843373493975903 Palmitolate(s) 76 16 1 - - - - - 25 Pantothenate(s)_waste -1 Pantothenate(s) DES +CoA(c) Pantothenate(s) test that Pantothenate can be degraded using the digestion target set 5.68083 O2(s) 3 Pi(s) 5 NH3(s) 1.83333 Glucose(s) 1 Methionine(s) 1 Pantothenate(s) 18.4538834951456 H2O(s) 1 CoA(c) 3.41747572815534 CO2(s) 0.0364077669902915 Palmitolate(s) 87 25 - - - - - - 36 Deoxycytidine(s)_waste -1 Deoxycytidine(s) DES Deoxycytidine(s) test that Deoxycytidine can be degraded using the digestion target set 3.58887 H2O(s) 0.977981 O2(s) 1 Deoxycytidine(s) 3.19044988645431 CO2(s) 3 NH3(s) 0.476881687432231 Glucose(s) 0.0277419750813232 Cholesterol(b) 0.137451666359784 Palmitolate(s) 69 16 19 6 - - - - 41 Trehalose(s)_waste -1 Trehalose(s) DES Trehalose(s) test that Trehalose can be degraded using the digestion target set 1 H2O(s) 1 Trehalose(s) 1.99999999999994 Glucose(s) - - - - - - 1 - - NH4+(s)_waste -1 NH4+(s) DES NH4+(s) test that NH4+ can be degraded using the digestion target set 1 NH4+(s) 1.00000000000003 NH3(s) - - - - - - 1 - - Cys-Gly(s)_waste -1 Cys-Gly(s) DES Cys-Gly(s) test that Cys-Gly can be degraded using the digestion target set 4.57708 H2O(s) 9.99263 O2(s) 1.91421 Tryptophan(s) 1 Cys-Gly(s) 10.5650134048258 CO2(s) 2.91420911528151 NH3(s) 1.20297140303841 Glucose(s) 1 Methionine(s) 0.957104557640754 Urea(s) 0.0857908847185004 Cholesterol(b) 50 24 19 6 - - 1 - 46 Stearate(s)_waste -1 Stearate(s) DES Stearate(s) test that Stearate can be degraded using the digestion target set 1.4788 O2(s) 1 Stearate(s) 1.65253026663368 H2O(s) 0.65253026663368 CO2(s) 0.51060230002474 Oleate(c) 0.48939769997526 Palmitolate(s) 23 35 - - - - - - 23 L-Cystathionine(c)_waste -1 L-Cystathionine(c) DES L-Cystathionine(c) test that L-Cystathionine can be degraded using the digestion target set 5.16176 H2O(s) 0.838235 O2(s) 1 Histidine(s) 1 L-Cystathionine(c) 2.83823529411765 CO2(s) 4 NH3(s) 0.860294117647059 Glucose(s) 1 Methionine(s) 23 11 1 - - - - - 25 Lactose-6P(s)_waste -1 Lactose-6P(s) DES Lactose-6P(s) test that Lactose-6P can be degraded using the digestion target set 1.8125 H2O(s) 0.1875 O2(s) 1 Lactose-6P(s) 0.99999999999997 Pi(s) 0.1875 CO2(s) 1.96874999999994 Glucose(s) 15 11 1 - - - 2 - 19 Galactosylglycerol(s)_waste -1 Galactosylglycerol(s) DES Galactosylglycerol(s) test that Galactosylglycerol can be degraded using the digestion target set 0.590909 O2(s) 1 Galactosylglycerol(s) 0.0909090909091208 H2O(s) 0.0909090909090909 CO2(s) 1.48484848484848 Glucose(s) 15 12 1 - - - 1 - 20 Alanine(l)_waste -1 Alanine(l) DES Alanine(l) test that Alanine can be degraded using the digestion target set 0.596542 H2O(s) 0.302594 O2(s) 1 Alanine(l) 0.390009606147935 CO2(s) 1 NH3(s) 0.399135446685879 Glucose(s) 0.0134486071085495 Palmitolate(s) 57 16 1 - - - - - 27 2-Lysolecithin-pool(l) -1 2-Lysolecithin-pool(l) DES 2-Lysolecithin-pool(l) test that 2-Lysolecithin-pool can be degraded using the digestion target set 1.12305 H2O(s) 1.12508 O2(s) 1 2-Lysolecithin-pool(l) 1 Pi(s) 0.373209632919123 CO2(s) 0.43779839451348 Glucose(s) 1 Choline(c) 0.0848527349228611 Arachidonate(s) 0.288686302010285 Oleate(c) 0.27466105656849 Linoleate(s) 0.351799906498364 Palmitolate(s) 46 8 1 - - - - - 29 Cholesterol(l) -1 Cholesterol(l) DES Cholesterol(l) test that Cholesterol can be degraded using the digestion target set 0.216216 O2(s) 0.036036 Valine(s) 1 Cholesterol(l) 0.144144144144144 H2O(s) 0.18018018018018 CO2(s) 0.036036036036036 NH3(s) 1 Cholesterol(b) - 23 - - - - - - 18 Arachidonate(l) -1 Arachidonate(l) DES Arachidonate(l) test that Arachidonate can be degraded using the digestion target set 1 Arachidonate(l) 1 Arachidonate(s) - - - - - - - - 4 Cholesterol-ester-arach(l) -1 Cholesterol-ester-arach(l) DES Cholesterol-ester-arach(l) test that Cholesterol-ester-arach can be degraded using the digestion target set 0.855856 H2O(s) 0.216216 O2(s) 0.036036 Valine(s) 1 Cholesterol-ester-arach(l) 0.18018018018018 CO2(s) 0.036036036036036 NH3(s) 1 Cholesterol(b) 1 Arachidonate(s) - 23 - - 1 - - - 23 Cholesterol-ester-stea(l) -1 Cholesterol-ester-stea(l) DES Cholesterol-ester-stea(l) test that Cholesterol-ester-stea can be degraded using the digestion target set 1.62468 O2(s) 1 Cholesterol-ester-stea(l) 0.749787847590775 H2O(s) 0.749787847590773 CO2(s) 1 Cholesterol(b) 0.43765911430692 Oleate(c) 0.56234088569308 Palmitolate(s) 23 35 - - 1 - - - 26 Cholesterol-ester-lin(l) -1 Cholesterol-ester-lin(l) DES Cholesterol-ester-lin(l) test that Cholesterol-ester-lin can be degraded using the digestion target set 0.711712 H2O(s) 0.432432 O2(s) 0.0720721 Valine(s) 1 Cholesterol-ester-lin(l) 0.36036036036036 CO2(s) 0.0720720720720721 NH3(s) 1 Cholesterol(b) 1 Linoleate(s) - 23 - - 1 - - - 21 Cholesterol-ester-palm(l) -1 Cholesterol-ester-palm(l) DES Cholesterol-ester-palm(l) test that Cholesterol-ester-palm can be degraded using the digestion target set 1.38095 O2(s) 0.146825 Glucose(s) 1 Cholesterol-ester-palm(l) 0.880952380952381 H2O(s) 0.880952380952381 CO2(s) 1 Cholesterol(b) 1 Palmitolate(s) 27 8 - - 1 - - - 21 Cholesterol-ester-ol(l) -1 Cholesterol-ester-ol(l) DES Cholesterol-ester-ol(l) test that Cholesterol-ester-ol can be degraded using the digestion target set 0.855856 H2O(s) 0.216216 O2(s) 0.036036 Valine(s) 1 Cholesterol-ester-ol(l) 0.18018018018018 CO2(s) 0.036036036036036 NH3(s) 1 Cholesterol(b) 1 Oleate(c) - 23 - - 1 - - - 20 Cholesterol-ester-pool(l) -1 Cholesterol-ester-pool(l) DES Cholesterol-ester-pool(l) test that Cholesterol-ester-pool can be degraded using the digestion target set 0.413906 H2O(s) 0.513773 O2(s) 0.0600073 Glucose(s) 1 Cholesterol-ester-pool(l) 0.40074748298937 CO2(s) 1 Cholesterol(b) 0.059092891408635 Arachidonate(s) 0.223506323593546 Oleate(c) 0.532054077627562 Linoleate(s) 0.185346707370257 Palmitolate(s) 21 38 - - 6 - - - 32 1,2-Diacylglycerol-VLDL-PC-pool(c) -1 1,2-Diacylglycerol-VLDL-PC-pool(c) DES 1,2-Diacylglycerol-VLDL-PC-pool(c) test that 1,2-Diacylglycerol-VLDL-PC-pool can be degraded using the digestion target set 1.71344 O2(s) 1 1,2-Diacylglycerol-VLDL-PC-pool(c) 0.514591922025302 H2O(s) 0.507111791123011 CO2(s) 0.483010327680734 Glucose(s) 0.169705469845722 Arachidonate(s) 0.273492286115007 Oleate(c) 0.54932211313698 Linoleate(s) 1.00748013090229 Palmitolate(s) 31 35 1 - - - - - 31 Phosphatidate-VLDL-PC-pool(c) -1 Phosphatidate-VLDL-PC-pool(c) DES Phosphatidate-VLDL-PC-pool(c) test that Phosphatidate-VLDL-PC-pool can be degraded using the digestion target set 0.231315 H2O(s) 1.8097 O2(s) 1 Phosphatidate-VLDL-PC-pool(c) 0.999999999999998 Pi(s) 0.761204942459316 CO2(s) 0.388052094343709 Glucose(s) 0.169705469845722 Arachidonate(s) 0.510234472629393 Oleate(c) 0.54932211313698 Linoleate(s) 0.770737944387905 Palmitolate(s) 36 36 1 - - - - - 31 PC-VLDL-pool(l) -1 PC-VLDL-pool(l) DES PC-VLDL-pool(l) test that PC-VLDL-pool can be degraded using the digestion target set 1.23131 H2O(s) 1.8097 O2(s) 1 PC-VLDL-pool(l) 1 Pi(s) 0.761204942459316 CO2(s) 0.388052094343709 Glucose(s) 1 Choline(c) 0.169705469845722 Arachidonate(s) 0.510234472629393 Oleate(c) 0.54932211313698 Linoleate(s) 0.770737944387904 Palmitolate(s) 37 36 1 - - - - - 33 PS-VLDL-pool(l) -1 PS-VLDL-pool(l) DES PS-VLDL-pool(l) test that PS-VLDL-pool can be degraded using the digestion target set 1.44593 H2O(s) 2.11503 O2(s) 1 PS-VLDL-pool(l) 1 Pi(s) 1.67598214570871 CO2(s) 1 NH3(s) 0.720669642381882 Glucose(s) 0.59613319011817 Arachidonate(s) 0.708378088077357 Oleate(c) 0.357142857142868 Linoleate(s) 0.338345864661664 Palmitolate(s) 38 9 1 - - - - - 31 PE-VLDL-pool(l) -1 PE-VLDL-pool(l) DES PE-VLDL-pool(l) test that PE-VLDL-pool can be degraded using the digestion target set 1.45058 H2O(s) 1.71254 O2(s) 1 PE-VLDL-pool(l) 1 Pi(s) 0.671335991746032 CO2(s) 0.422163824692632 Glucose(s) 1.00000000000003 Ethanolamine(c) 0.59613319011817 Arachidonate(s) 0.555138883150989 Oleate(c) 0.357142857142868 Linoleate(s) 0.491585069588032 Palmitolate(s) 37 36 1 - - - - - 33 Fatty-acid-VLDL-SM-pool(c) -1 Fatty-acid-VLDL-SM-pool(c) DES Fatty-acid-VLDL-SM-pool(c) test that Fatty-acid-VLDL-SM-pool can be degraded using the digestion target set 1.05555 O2(s) 0.0464346 Glucose(s) 1 Fatty-acid-VLDL-SM-pool(c) 1.38216258787497 H2O(s) 0.503776551379423 CO2(s) 0.0166609996599801 Arachidonate(s) 0.074351127734333 Oleate(c) 0.0306018361101675 Linoleate(s) 0.878386036495549 Palmitolate(s) 30 36 - - - - - - 27 Dihydroceramide-pool(c) -1 Dihydroceramide-pool(c) DES Dihydroceramide-pool(c) test that Dihydroceramide-pool can be degraded using the digestion target set 2.19188 O2(s) 1 Dihydroceramide-pool(c) 1.13107494718365 H2O(s) 0.252688910688133 CO2(s) 1 NH3(s) 0.291218514885311 Glucose(s) 0.0166609996599796 Arachidonate(s) 0.243227927008954 Oleate(c) 0.0306018361101666 Linoleate(s) 1.7095092372209 Palmitolate(s) 47 8 3 - - - - - 29 Sphinganine(c) -1 Sphinganine(c) DES Sphinganine(c) test that Sphinganine can be degraded using the digestion target set 1.32491 O2(s) 0.0338174 CO2(s) 1 Sphinganine(c) 0.993926496523647 H2O(s) 1 NH3(s) 0.283068563389176 Glucose(s) 0.00607350347635372 Cholesterol(b) 0.00952341410051796 Oleate(c) 1 Palmitolate(s) 88 15 19 6 - - - - 40 Ceramide-pool(c) -1 Ceramide-pool(c) DES Ceramide-pool(c) test that Ceramide can be degraded using the digestion target set 0.0800813 H2O(s) 1.22117 O2(s) 1 Ceramide-pool(c) 1 NH3(s) 0.252526023703702 Glucose(s) 0.0084971454482365 Cholesterol(b) 0.259269200897585 Oleate(c) 0.0472628357701462 Linoleate(s) 1.7095092372209 Palmitolate(s) 93 15 21 6 - - - - 44 SM-pool(l) -1 SM-pool(l) DES SM-pool(l) test that SM-pool can be degraded using the digestion target set 2.08008 H2O(s) 1.22117 O2(s) 1 SM-pool(l) 1 Pi(s) 1 NH3(s) 0.252526023703702 Glucose(s) 1 Choline(c) 0.00849714544823649 Cholesterol(b) 0.259269200897585 Oleate(c) 0.0472628357701462 Linoleate(s) 1.7095092372209 Palmitolate(s) 98 14 21 6 - - - - 48 CDP-diacylglycerol-VLDL-PI-pool(l) -1 CDP-diacylglycerol-VLDL-PI-pool(l) DES CDP-diacylglycerol-VLDL-PI-pool(l) test that CDP-diacylglycerol-VLDL-PI-pool can be degraded using the digestion target set 7.12652 H2O(s) 1.79737 O2(s) 1 CDP-diacylglycerol-VLDL-PI-pool(l) 2 Pi(s) 2.78466983546376 CO2(s) 3 NH3(s) 1.33333333333333 Glucose(s) 0.507127833605983 Arachidonate(s) 1.16849731245618 Oleate(c) 0.162187426968918 Linoleate(s) 0.238145562252433 Palmitolate(s) 84 18 2 - - - 2 - 36 PI-pool(l) -1 PI-pool(l) DES PI-pool(l) test that PI-pool can be degraded using the digestion target set 1.20646 H2O(s) 1.95545 O2(s) 1 PI-pool(l) 1 Pi(s) 0.780682775636492 CO2(s) 1.42599999821719 Glucose(s) 0.507127833605983 Arachidonate(s) 0.915985238751443 Oleate(c) 0.162187426968918 Linoleate(s) 0.414699500673657 Palmitolate(s) 37 36 1 - - - - - 33 LDL(s)_waste -1 LDL(s) DES LDL(s) test that LDL can be degraded using the digestion target set 2731.3 H2O(s) 5310.18 O2(s) 180.097 Tryptophan(s) 1 LDL(s) 859.999999999996 Pi(s) 6290.14825971638 CO2(s) 2569.43741649802 NH3(s) 781.721457070771 Glucose(s) 357 Lysine(s) 104 Methionine(s) 224 Phenylalanine(s) 817.878213557438 Urea(s) 609.999999999983 Choline(c) 533 Leucine(s) 115 Histidine(s) 252 Valine(s) 2209.90307819345 Cholesterol(b) 300 Threonine(s) 29.9999999999982 Ethanolamine(c) 205.331841769085 Arachidonate(s) 285 Isoleucine(s) 826.164564699742 Oleate(c) 1114.61539767991 Linoleate(s) 1054.88041530007 Palmitolate(s) 138 32 23 6 10 - - - 105 HDL(s)_waste -1 HDL(s) DES HDL(s) test that HDL can be degraded using the digestion target set 795.428 H2O(s) 576.82 O2(s) 8.47471 Histidine(s) 1 HDL(s) 220 Pi(s) 487.453115121787 CO2(s) 556.424124513619 NH3(s) 266.687126727433 Glucose(s) 44 Lysine(s) 8 Methionine(s) 10 Tryptophan(s) 16 Phenylalanine(s) 34 Urea(s) 165 Choline(c) 82 Leucine(s) 30 Valine(s) 21.5252918287938 Cholesterol(b) 24 Threonine(s) 25.0000000000007 Ethanolamine(c) 45.4971631451284 Arachidonate(s) 109.166423731778 Oleate(c) 75.1902146054329 Linoleate(s) 210.690945599377 Palmitolate(s) 106 17 18 6 2 - - - 95 VLDL(s)_waste -1 VLDL(s) DES VLDL(s) test that VLDL can be degraded using the digestion target set 9206.71 H2O(s) 31329.7 O2(s) 259.498 Tryptophan(s) 1 VLDL(s) 3271.00000000001 Pi(s) 17307.1681670196 CO2(s) 4764.99610894942 NH3(s) 6879.47132365513 Glucose(s) 448 Lysine(s) 174 Methionine(s) 252 Phenylalanine(s) 1164 Urea(s) 3085 Choline(c) 820 Leucine(s) 129 Histidine(s) 420 Valine(s) 2164.50194552534 Cholesterol(b) 384 Threonine(s) 185.000000000006 Ethanolamine(c) 1472.94114062486 Arachidonate(s) 299 Isoleucine(s) 15498.2626743094 Oleate(c) 9451.75523241822 Linoleate(s) 12761.0059331932 Palmitolate(s) 129 24 18 6 11 - - - 103 Lysine(s)_waste -1 Lysine(s) DES Lysine(s) test that Lysine can be degraded using the digestion target set 1.375 O2(s) 1 Lysine(s) 0.25 H2O(s) 2 CO2(s) 2 NH3(s) 0.25 Palmitolate(s) 1.85416666666667 ATP-energy(m) 47 15 - - - - - - 23 Formaldehyde(s)_waste -1 Formaldehyde(s) DES Formaldehyde(s) test that Formaldehyde can be degraded using the digestion target set 1 O2(s) 1 Formaldehyde(s) 1 H2O(s) 1 CO2(s) 14 - - - - - - - 12 Leucine(s)_waste -1 Leucine(s) DES Leucine(s) test that Leucine can be degraded using the digestion target set 1.18557 O2(s) 0.00660896 Glucose(s) 1 Leucine(s) 0.816815260211485 H2O(s) 1.52418964683116 CO2(s) 1 NH3(s) 0.00793074849678617 Cholesterol(b) 0.268833367889972 Palmitolate(s) 62 23 18 6 - - - - 39 Methanol(s)_waste -1 Methanol(s) DES Methanol(s) test that Methanol can be degraded using the digestion target set 4.15111 O2(s) 3.76 NH3(s) 0.5 Glucose(s) 1 Methanol(s) 0.0222222 Histidine(s) 0.173333 Valine(s) 9.69333333333332 H2O(s) 1 Urate(s) 52 23 - - - - - - 28 Threonine(s)_waste -1 Threonine(s) DES Threonine(s) test that Threonine can be degraded using the digestion target set 1 O2(s) 1 Threonine(s) 1 CO2(s) 1 NH3(s) 0.5 Glucose(s) 3.33333333333333 ATP-energy(m) 11 11 1 - - - - - 20 Riboflavin(s)_waste -1 Riboflavin(s) DES +FAD(c) Riboflavin(s) test that Riboflavin can be degraded using the digestion target set 3.81478 O2(s) 2 Pi(s) 2 NH3(s) 1.33333 Glucose(s) 1 Histidine(s) 1 Riboflavin(s) 10.8765182186235 H2O(s) 2.80161943319838 CO2(s) 0.99999999999994 FAD(c) 0.0748987854251011 Palmitolate(s) 84 17 - - - - - - 34 Isoleucine(s)_waste -1 Isoleucine(s) DES Isoleucine(s) test that Isoleucine can be degraded using the digestion target set 1.6875 O2(s) 1 Isoleucine(s) 0.125 H2O(s) 1 CO2(s) 1 NH3(s) 0.5 Glucose(s) 0.125 Palmitolate(s) 3.8125 ATP-energy(m) 57 22 1 - - - - - 28 Bilirubin(s)_waste -1 Bilirubin(s) DES +Bilirubin-bisglucuronoside(b) Bilirubin(s) test that Bilirubin can be degraded using the digestion target set 2.20339 O2(s) 2 Glucose(s) 0.0338983 Valine(s) 1 Bilirubin(s) 4.13559322033898 H2O(s) 0.169491525423729 CO2(s) 0.0338983050847458 NH3(s) 1.00000000000003 Bilirubin-bisglucuronoside(b) 9 22 2 - - - - - 30 Xanthine(c)_waste -1 Xanthine(c) DES Xanthine(c) test that Xanthine can be degraded using the digestion target set 0.693548 O2(s) 0.0322581 Valine(s) 1 Xanthine(c) 0.129032258064516 H2O(s) 0.161290322580645 CO2(s) 0.032258064516129 NH3(s) 1 Urate(s) 6 21 - - - - - - 22 Hypoxanthine(s)_waste -1 Hypoxanthine(s) DES Hypoxanthine(s) test that Hypoxanthine can be degraded using the digestion target set 1.30508 O2(s) 0.0508475 Valine(s) 1 Hypoxanthine(s) 0.203389830508475 H2O(s) 0.254237288135593 CO2(s) 0.0508474576271186 NH3(s) 1 Urate(s) 14 21 - - - - - - 24 IMP(c)_waste -1 IMP(c) DES IMP(c) test that cytosolic IMP can be degraded using the digestion target set 2 H2O(s) 1 O2(s) 1 IMP(c) 1 Pi(s) 0.833333333333333 Glucose(s) 0.999999999999999 Urate(s) 20 - 1 - - - - - 16 AMP(c)_waste -1 AMP(c) DES AMP(c) test that cytosolic AMP can be degraded using the digestion target set 3 H2O(s) 1 O2(s) 1 AMP(c) 1 Pi(s) 1 NH3(s) 0.833333333333333 Glucose(s) 1 Urate(s) 21 - 1 - - - - - 17 ADP(c)_waste -1 ADP(c) DES ADP(c) test that ADP can be degraded using the digestion target set 4 H2O(s) 1 O2(s) 1 ADP(c) 2 Pi(s) 1 NH3(s) 0.833333333333333 Glucose(s) 1 Urate(s) 20 - 1 - - - - - 9 ATP(s)_waste -1 ATP(s) DES ATP(s) test that ATP can be degraded using the digestion target set 5 H2O(s) 1 ATP(s) 1 O2(s) 3 Pi(s) 1 NH3(s) 0.833333333333333 Glucose(s) 1 Urate(s) 20 - 1 - - - - - 10 Acetyl-CoA(c)_waste -1 Acetyl-CoA(c) DES +CoA(c) Acetyl-CoA(c) test that Acetyl-CoA can be degraded using the digestion target set 0.0932471 H2O(s) 0.317092 O2(s) 1 Acetyl-CoA(c) 0.00717286 Glucose(s) 1 CoA(c) 0.818950170247334 CO2(s) 0.00860742866031767 Cholesterol(b) 0.0619803999516048 Palmitolate(s) 61 9 19 6 - - - - 35 Biotransformation and catabolic functions Diseases Farnesyl_Statin HC00362(p) MES % exclude(s) tests that no faresyl diphosphate can be produced if HMG-CoA reductase is inhibited (statin target) - - - - - - - - - Cholesterol_Statin Cholesterol(b) MES % exclude(s) tests that no cholesterol can be produced if HMG-CoA reductase is inhibited (statin target) - - - - - - - - - Hypoxic liver ATP(c) HES +ADP(c) exclude(s) tests that no ATP can be rephosphosphorylated if no oxygene is given - - - - - - - - - GlycogenoseI Glucose(s) -Glycogenin-G11(c) -O2(s) +CO2(s) -ADP(c) =Pi(c) % +r0206(s) -r0094(s) exclude(s) - - - - - - - - - Galactosemia1 -1 Galactose(s) WES =H2O(s) % exclude(s) tests that no galactose can be degraded for the enzyme deficiency specific to Galactosemia 1 - - - - - - - - - Galactosemia2 -1 Galactose(s) WES =H2O(s) % exclude(s) tests that no galactose can be degraded for the enzyme deficiency specific to Galactosemia 2 - - - - - - - - - Galactosemia3 -1 Galactose(s) WES =H2O(s) % exclude(s) tests that no galactose can be degraded for the enzyme deficiency specific to Galactosemia 3 - - - - - - - - - LactoseIntolerance -1 Lactose(s) WES =H2O(s) % exclude(s) tests that no lactose can be degraded for the enzyme deficiency specific to Lactose intolerance - - - - - - - - - Sucroseintolerance -1 Sucrose(s) WES =H2O(s) % exclude(s) tests that no sucrose can be degraded for the enzyme deficiency specific to Sucrose intolerance - - - - - - - - -